ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG Ở BỆNH NHÂN BỆNH NẤM ASPERGILLUS PHỔI MẠN TÍNH

Abstract

Objectives: To describe clinical and subclinical characteristics in patients with chronic pulmonary aspergillosis (CPA). Subjects and methods: A retrospective, prospective, cross-sectional study on 50 patients with CPA who were diagnosed and treated at the National Lung Hospital from January 2022 to November 2022. Results: The mean age is 57 ± 11years old, with the proportion of men being 78%. History of pulmonary tuberculosis accounts for the highest rate (76%), following by diabetes (20%). The time of disease detection is late with an average time of 8.22 ± 10.4 months. Common clinical symptoms are cough, sputum production (72%) and hemoptysis (56%). Lesions on chest CT are mainly in the upper lobe (95%), with cavities (86%) and aspergilloma (76%). Fungal culture with positive results accounts for 26.7% - 36.4%, in which Aspergillus fumigatus accounts for 95%; Aspergillus Galactomannan test with positive results accounts for 80% - 97.1%. Conclusion: The disease is common in men, middle-aged, with a history of pulmonary tuberculosis and detected late. Cough, sputum production and hemoptysis are the main clinical manifestations. Radiographic lesions are predominantly in the upper lobes with predominant cavities and aspergilloma. Fungal cultures with positive results account for a low percentage and most of them are Aspergillus fumigatus. Aspergillus Galactomannan tests with positive results account for a high percentage.