MỐI LIÊN QUAN GIỮA MỘT SỐ TRIỆU CHỨNG TÂM THẦN VỚI KẾT QUẢ ĐIỀU TRỊ VIÊM NÃO TỰ MIỄN DO KHÁNG THỂ KHÁNG THỤ THỂ N-METHYL-D-ASPARTATE

Abstract

Objective: To evaluate the association between several psychiatric symptoms and the outcomes of N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis) treatment. Subjects: 40 patients diagnosed and treated for anti-NMDAR encephalitis between 01/2020 and 10/2022 at the Neurology Center of Bach Mai Hospital. Methods: Cross-sectional analytical study. Patients with a modified Rankin Scale (mRS) score of ≤ 2 at discharge were classified as good treatment outcome, and patients with a modified Rankin Scale (mRS) score of > 2 at discharge were classified as poor treatment outcome. Then, we evaluated the relationship between psychiatric symptoms and the treatment outcomes. Results: Among the 40 study patients, the mean age was 33.68 ± 13.81, with a predominant female proportion (65%). The most common symptoms were cognitive decline (75%), followed by inappropriate thinking and bizarre behavior, language progression decline, and delusions at rates of 57.5%, 57.5%, and 52.5%, respectively. The treatment outcome showed 17 patients (42.5%) achieved good results, while 23 patients (57.5%) had poor outcome. The analysis revealed that patients with inappropriate thinking and bizarre behavior symptoms had a 5.194-fold higher risk of poor outcomes than those without these symptoms (p <0.05). Conclusion: In summary, our study revealed that anti-NMDAR encephalitis patients with inappropriate thinking and bizarre behavior symptoms had a 5.194-fold higher risk of poor outcomes than those without these symptoms (95% CI 1.33 - 20.284, p <0.05).