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QUANTITATIVE STUDY TWO COMPONENT MIXTURE CONTAINING PARACETAMOL AND IBUPROFEN IN SOLID PHARMACEUTICAL DOSAGE FORMS BY RATIO ULTRAVIOLET SPECTROSCOPY
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Abstract
Using ratio ultraviolet spectroscopy to determine the concentration of substances in a two component mixture containing paracetamol (PA) and ibuprofen (IBU) without chemical treatment, the solvent used in the analysis is methanol. The relative ultraviolet spectroscopy method is based on the difference between the peak amplitude of the proportional spectrum at two wavelengths to build regression equations and analytical parameters. The two wavelengths selected in the ratio spectrum for PA, IBU are 247 and 272 nm, 217 and 245 nm, respectively. The concentration range considered linear for the two substances is 4- 32 µg/ml; The LOD and LOQ of PA, IBU were 0.50, 1.13 µg/ml and 1.51, 3.39 µg/ml, respectively. The ratio ultraviolet spectroscopy method has successfully determined the concentrations of the two substances in a mixture of laboratory and three commercial drugs.
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Keywords
paracetamol, ibuprofen, ratio ultraviolet spectroscopy, quantitative, mixture
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