MỐI LIÊN QUAN GIỮA MỘT SỐ YẾU TỐ LÂM SÀNG, CẬN LÂM SÀNG VÀ TỔN THƯƠNG ỐNG THẬN MÔ KẼ TRONG BỆNH THẬN IGA

Abstract

Objectives: To evaluate the characteristics of tubulointerstitial injury and identify the relationship between some clinical, paraclinical factors and tubulointerstitial injury in IgA nephropathy. Methods: A cross-sectional, descriptive study was conducted in patients aged 18 years or older, diagnosed with IgA nephropathy at the Nephrology Department, Thong Nhat Hospital from July 2014 to July 2022. Patients with secondary IgA nephropathy or tissue samples, which were not satisfactory for histopathological diagnosis were excluded from this study. Clinical and subclinical characteristics of patients with and without tubulointerstitial injury were compared. Results: We included 43 patients in this study. The mean age of patients with IgA nephropathy was 34 (27-44), male was 53.3%. Nephrotic syndrome and hypertension accounted for 23.3% and 58.1%, respectively. Glomerular filtration rate at the time of diagnosis was 70.5±38.4 (mL/min), hematuria-74%, hemoglobin-12.2±2.2 (g/dL). The percentage of IgA patients with tubulointerstitial injury according to Oxford classification T0, T1, T2 was 55.8%, 39.5% and 4.7%, respectively. Patients with tubulointerstitial injury had higher rates of hypertension, nephrotic syndrome and proteinuria than patients without. IgA nephropathy patients with tubulointerstitial injury had a lower glomerular filtration rate compared with the patients without (p< 0.05). Conclusions: The proportion of IgA nephropathy patients with tubulointerstitial injury accounted for 45.2%. It’s need to control hypertension, proteinuria and glomerular filtration in patients with renal tubulointerstitial injury help limit its progression.