ĐẶC ĐIỂM THAI TRỨNG BÁN PHẦN TẠI BỆNH VIỆN TỪ DŨ

Abstract

Background: Partial hydatidiform mole (PHM) are undertood to be at low risk of becoming malignancy because of the low likelihood of progression to gestional trophoblastic neoplasia (GTN). In Viet Nam, there has been few studies of PHM with small sample size. Acknowledging rate of postmolar GTN in PHM patients improves consultation, prophylatic treatment and follow-up. Objectives: The study aimed to determine the gestational trophoblastic neoplasia (GTN) rate and associated factors associated of partial hydatidiform mole (PHM). Methods: This is a retrospective cohort  study with 370 patients who were diagnosed PHM based on histology by uterine evacuation at Tu Du hospital from 01/2020 to 12/2021. Results: Followed-up by 1 year, 21 patients developed GTN, the incidence of GTN was 5.7% (95%CI: 3.5-8.4). The median time progressed GTN was 4,67±2,23 weeks. The highest rate of GTN was recognized at the third an sixth week after evacuation. Applying multivariate model, the rate of GTN was significantly higher in group of patients who had history of miscarriage/abortion (HR=2.84 95%CI:1.05-7.69). Conclusions: The rate of postmolar GTN in PHM patients was 5.7%. Patients who had history of miscarriage/abortion were 2.84 times more likely to develop GTN than patients who did not.