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Date Published: 27/06/2023
Abstract Views: 275
Views PDF: 212
DOI: https://doi.org/10.51298/vmj.v527i1B.5745
Issue
Vol. 527 No. 1B (2023)
Section
Các bài báo
How to Cite
Phạm, V. H., Mai, P. Q., Lê, Đình Q., Trần, T. H. Y., & Nguyễn, T. T. D. (2023). FORMULATION OF CEFUROXIME AXETIL MICROPARTICLES FOR DRY ORAL SUSPENSION. Vietnam Medical Journal, 527(1B). https://doi.org/10.51298/vmj.v527i1B.5745

FORMULATION OF CEFUROXIME AXETIL MICROPARTICLES FOR DRY ORAL SUSPENSION

Văn Hùng Phạm1, Phương Quỳnh Mai1, Đình Quang Lê1, Thị Hải Yến Trần1, Thị Thanh Duyên Nguyễn1,
1 Hanoi University of Pharmacy

Main Article Content

Abstract

Objectives: To prepare taste-masked cefuroxime acetil (CFA) microparticles and a taste-masked dry oral suspension containing 150 mg CFA on the laboratory scale. Methods: Microparticles containing CFA were prepared by melting method with stearic acid and other suitable excipients; the dry oral suspension containing CFA was prepared from CFA microparticles and excipients of the suspension. Results: CFA microparticles and dry oral suspension reduced the concentration of CFA released in the dispersion medium (reduced bitterness) and met the dissolution requirement according to USP 43-NF 38

Article Details

Keywords

Keywords: cefuroxime acetil (CFA), microparticles, solid dispersion systems, stearic acid, taste-masking.

References

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1. Bộ Y Tế (2018), Dược điển Việt Nam V, Nhà xuất bản Y học, trang 238-240.
2. Bilgic M. (2011), "Pharmaceutical formulation comprising cefuroxime axetil", European Patent Office.
3. Commission European Pharmacopoeia (2019), "European Pharmacopoeia 10.0", European Directorate for the Quality of Medicines (EDQM), pp. 310-311.
4. Manish D. et al (2013), "Pharmaceutical composition comprising cefuroxime axetil", International search report.
5. The United States Pharmacopeial Convention (2020), The United States Pharmacopoeia, pp. 3311.
6. Yuqian D. et al (2013), "Development and evaluation of taste-masked dry suspension of cefuroxime axetil for enhancement of oral bioavailability", Asian Journal of Pharmaceutical Sciences, 8(5), pp. 287-294.