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Date Published: 27/06/2023
Abstract Views: 165
Views PDF: 111
DOI: https://doi.org/10.51298/vmj.v527i1B.5750
Issue
Vol. 527 No. 1B (2023)
Section
Các bài báo
How to Cite
Lê, T. T. A., Trần, T. T., Nguyễn, T. H., & Nguyễn, V. T. (2023). ASSOCIATION BETWEEN ENVIRONMENTAL FACTORS AND YOUNG-ONSET PARKINSON’S DISEASE. Vietnam Medical Journal, 527(1B). https://doi.org/10.51298/vmj.v527i1B.5750

ASSOCIATION BETWEEN ENVIRONMENTAL FACTORS AND YOUNG-ONSET PARKINSON'S DISEASE

Thị Thúy An Lê1,, Thanh Tú Trần2, Thi Hùng Nguyễn3, Văn Tuấn Nguyễn4
1 UMP
2 Cho Ray hospital
3 Hai Phong University Of Medicine And Pharmacy
4 New South Wales university

Main Article Content

Abstract

Objective: To define the association between environmental factors and the onset of Parkinson's disease in young people. Subjects and methods: The study was designed in a case-control investigation with 100 patients with Parkinson's onset under 50 years of age and 100 patients without Parkinson's disease. Patients were recruited at the neurology clinic of Cho Ray Hospital from July 2020 to July 2022. Patients were directly interviewed and examined based on a set of structured questionnaires. The logistic regression model was used to quantify the association between risk factors and Parkinson's disease. Result: On average, the Parkinson's disease group was older than the controls (43 vs 36; P < 0.01), but there was no significant difference in gender distribution between the two groups (P = 0.57). Logistic regression analysis identified several risk factors for Parkinson's disease, including well water usage (OR = 2.4; 95% CI: 1.3 - 4.6), exposure to pesticides (OR = 4.1; 95% CI: 2.2 – 7.4), living in rural areas (OR = 6.3; 95% CI: 3.4 - 11.7), and manual labor (OR = 7.1; 95% CI: 3.6 – 14.2). Conclusion: This study suggests that young-onset Parkinson's disease is associated with environmental factors, especially pesticide exposure and well water usage in rural areas. These findings may help clinicians to identify young individuals at high risk of developing Parkinson's disease.

Article Details

Keywords

Young-onset Parkinson's disease, environmental factors, disease control.

References

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