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Date Published: 27/06/2023
Abstract Views: 145
Views PDF: 86
DOI: https://doi.org/10.51298/vmj.v527i1B.5750
Issue
Vol. 527 No. 1B (2023)
Section
Các bài báo
How to Cite
Lê, T. T. A., Trần, T. T., Nguyễn, T. H., & Nguyễn, V. T. (2023). ASSOCIATION BETWEEN ENVIRONMENTAL FACTORS AND YOUNG-ONSET PARKINSON’S DISEASE. Vietnam Medical Journal, 527(1B). https://doi.org/10.51298/vmj.v527i1B.5750

ASSOCIATION BETWEEN ENVIRONMENTAL FACTORS AND YOUNG-ONSET PARKINSON'S DISEASE

Thị Thúy An Lê1,, Thanh Tú Trần2, Thi Hùng Nguyễn3, Văn Tuấn Nguyễn4
1 UMP
2 Cho Ray hospital
3 Hai Phong University Of Medicine And Pharmacy
4 New South Wales university

Main Article Content

Abstract

Objective: To define the association between environmental factors and the onset of Parkinson's disease in young people. Subjects and methods: The study was designed in a case-control investigation with 100 patients with Parkinson's onset under 50 years of age and 100 patients without Parkinson's disease. Patients were recruited at the neurology clinic of Cho Ray Hospital from July 2020 to July 2022. Patients were directly interviewed and examined based on a set of structured questionnaires. The logistic regression model was used to quantify the association between risk factors and Parkinson's disease. Result: On average, the Parkinson's disease group was older than the controls (43 vs 36; P < 0.01), but there was no significant difference in gender distribution between the two groups (P = 0.57). Logistic regression analysis identified several risk factors for Parkinson's disease, including well water usage (OR = 2.4; 95% CI: 1.3 - 4.6), exposure to pesticides (OR = 4.1; 95% CI: 2.2 – 7.4), living in rural areas (OR = 6.3; 95% CI: 3.4 - 11.7), and manual labor (OR = 7.1; 95% CI: 3.6 – 14.2). Conclusion: This study suggests that young-onset Parkinson's disease is associated with environmental factors, especially pesticide exposure and well water usage in rural areas. These findings may help clinicians to identify young individuals at high risk of developing Parkinson's disease.

Article Details

Keywords

Young-onset Parkinson's disease, environmental factors, disease control.

References

Al-Rumayyan A, Klein C, Alfadhel M. Early-Onset Parkinsonism: Case Report and Review of the Literature. Pediatr Neurol. (2017); 67: 102-106.
2. Bower JH, Maraganore DM, McDonnell SK, Rocca WA. Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976 - 1990. Neurology. (1999); 52: 1214-1220.
3. Firestone JA, Smith-Weller T, Franklin G, Swanson P, Longstreth WT, Checkoway H. Pesticides and Risk of Parkinson Disease: A Population-Based Case-Control Study. Arch Neurol. (2005); 62(1): 91-95.
4. Moretto A, Colosio C. Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease. Neurotoxicology. (2011); 32(4): 383-391.
5. Noyce A. J., Bestwick J. P., Silveira‐Moriyama L. et al., Meta‐analysis of early nonmotor features and risk factors for Parkinson disease. Annals of Neurology. (2012). 72(6): 893-901, 2012.
6. Post B, van den Heuvel L, van Prooije T, van Ruissen X, van de Warrenburg B, Nonnekes J. Young Onset Parkinson's Disease: A Modern and Tailored Approach. Journal of Parkinson's Disease. (2020); 10(1): 29-36.
7. Postuma BR, Berg D, Stern M, Poewe W. MDS clinical diagnostic criteria for Parkinson's disease. Official journal of the International Parkinson and Movement Disorder Society. (2015).
8. Shi Y, Zhang K và Ye M. Well-Water Consumption and Risk of Parkinson’s Disease: A Meta-Analysis of 15 Observational Studies. Neuropsychiatr Dis Treat. (2021); 17: 3705-3714.