TỶ LỆ VÀ MỐI LIÊN QUAN GIỮA NHIỄM VIRUS EPSTEIN-BARR VỚI UNG THƯ DẠ DÀY TẠI VIỆT NAM

Abstract

prevalence of EBV in the community, as well as in some cancers (nasopharyngeal cancer, Hogdkin lymphoma...). However, there have been no studies on the prevalence of EBV infection in patients with gastric cancer and other gastric diseases. This study aims to determine the status of EBV infection and the relationship of EBV with gastric cancer characteristics. Subjects and methods: A cross-sectional study of 623 patients with H. pylori infection, including: Gastric cancer (n=154), gastric ulcer (n=129), duodenal  ulcer (n=161) and chronic gastritis (n=179). Diagnosis of gastric cancer and chronic gastritiss based on histopathology. Cag-PAI status was determined by Realtime-PCR technique. Results on cag-PAI: (+) & (-) . Results: The rate of positive EBV in patients with gastric cancer (76.6%), gastric ulcer (72.1%), and duodenal ulcer (75.8%) were significantly higher (p < 0. 05) compared with the positive rate of EBV in patients with chronic gastritis. The Borrmann type III patient group had a higher rate of EBV infection (85.6%) than the Borrmann type I-II group (56.8%), (p < 0.05). The group of patients with diffuse/mixed with EBV infection (88.2%) was higher than the group with intestinal (67.4%), (p < 0.05). Conclusion: EBV infection may increase the risk of gastric cancer in Vietnam.