YẾU TỐ PROTEIN VIÊM MÀNG NGOÀI (OIPA) CỦA HELICOBACTER PYLORI Ở BỆNH NHÂN UNG THƯ DẠ DÀY TẠI VIỆT NAM

Abstract

Background: Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H. pylori, which play a vital role in severe clinical outcomes. Some other virulence factors (oipA, dupA, cag-PAI) have not been studied in Vietnam. Airm: Study to find out the role of oipA in gastric cancer patients in Vietnam. Subjects & methods: A cross-sectional study of 623 patients with H. pylori infection, including: Gastric cancer (n=154), gastric ulcer (n=129), duodenal  ulcer (n=161) and chronic gastritis (n=179). Diagnosis of GC and CG is based on histopathology. OipA status was determined by Realtime-PCR technique. Results: The rate of carrying the oipA gene in patients with gastric cancer (35%), gastric ulcer (34.1%) and duodenal ulcer (33.5%) was significantly higher (p < 0.05) than with the prevalence of oipA gene in patients with chronic gastritis (27.4%). There was no relationship between the percentage of oipA gene positive with age, sex, endoscopic morphology (Borrmann classification) and histopathological characteristics (Lauren classification). Conclusion: There was no association of oipA with age, sex, endoscopic morphology and histopathological characteristics in gastric cancer patients.