Article Sidebar
Views PDF: 630
FORMULATION OF ALPHA LIPOIC ACID TABLET 300 MG
Main Article Content
Abstract
Objectives: (i) Initially evaluating the effects of some formula factors on alpha lipoic acid (ALA) tablets’ sticking phenomenon during compaction process and tablets’ dissolution; (ii) Preparing 300 mg ALA tablets meeting the USP 41 requirement for dissolution test on a laboratory scale. Method: Tablets were prepared by wet-granulation method, evaluate the effects of some factors by experiments. Result: The selected fomula of ALA tablet contained: ALA: 300 mg, Avicel PH-102: 120 mg, sodium stearyl fumarate (NSF): 19,1 mg, Aerosil 200: 19,1 mg, talcum: 9,6 mg, disodium edetate (EDTA): 1 mg, hydroxypropyl cellulose (HPC): 12,2 mg, sodium croscarmellose (NCC): 25 mg, menthol: 12 mg, poloxamer: 6 mg, calcium carbonate: 20 mg, calcium hydrogen phosphate (DCP): 160,7 mg, ethanol 30% to pH 8,0: 300mg. The selected formula were successfully prepared on a scale of 1000 tablets without punch sticking and met the USP 41 requirement for dissolution test.
Article Details
Keywords
Acid alpha lipoic (ALA), dissolution, punch sticking, tablet
References
2. Anca L. P. et al. (2021), "Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid", Processes, 9(176), pp. 1-22.
3. Dilbir S. B. et al. (2013), "Incompatibility of croscarmellose sodium with alkaline excipients in a tablet formulation", Pharm Dev Technol, Early Online, pp. 1-5.
4. Kuralla H., Saripilli R., Kolapalli V. R. (2018), "Preparation and evaluation of orally disintegrating tablets of drotaverine hydrochloride using sublimation technique", International Journal of Pharmacy and Pharmaceutical Sciences, 10(5), pp. 85-95.
5. Mary T. E., David J. E. (2019), Chemical Engineering in the Pharmaceutical Industry: Drug Product Design, Development, and Modeling, John Wiley & Sons, pp. 227-243.
6. Raymond C. R, Paul J. S., Marian E. Q. (2009), Handbook of Pharmaceutical Excipients, Pharmaceutical Press, American Pharmacists Association, pp. 94-99, 433-435, 517-522.
7. The United States Pharmacopeial Convention (2018), The United States Pharmacopeia 41, pp. 4742-4743.
8. Zheng M. (2017), "Inclusion Complex of α-Lipoic Acid Containing Alkalizer for Improving the Solubility and Stability Prepared by Co-grinding", Indian Journal of Pharmaceutical Sciences, pp. 544-552.