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FORMULATION OF ALPHA LIPOIC ACID TABLET 300 MG
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Abstract
Objectives: (i) Initially evaluating the effects of some formula factors on alpha lipoic acid (ALA) tablets’ sticking phenomenon during compaction process and tablets’ dissolution; (ii) Preparing 300 mg ALA tablets meeting the USP 41 requirement for dissolution test on a laboratory scale. Method: Tablets were prepared by wet-granulation method, evaluate the effects of some factors by experiments. Result: The selected fomula of ALA tablet contained: ALA: 300 mg, Avicel PH-102: 120 mg, sodium stearyl fumarate (NSF): 19,1 mg, Aerosil 200: 19,1 mg, talcum: 9,6 mg, disodium edetate (EDTA): 1 mg, hydroxypropyl cellulose (HPC): 12,2 mg, sodium croscarmellose (NCC): 25 mg, menthol: 12 mg, poloxamer: 6 mg, calcium carbonate: 20 mg, calcium hydrogen phosphate (DCP): 160,7 mg, ethanol 30% to pH 8,0: 300mg. The selected formula were successfully prepared on a scale of 1000 tablets without punch sticking and met the USP 41 requirement for dissolution test.
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Keywords
Acid alpha lipoic (ALA), dissolution, punch sticking, tablet
References
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