ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ LOÃNG XƯƠNG NGUYÊN PHÁT BẰNG ACID ZOLEDRONIC (ZOLEDRO BFS) TẠI BỆNH VIỆN CHẤN THƯƠNG CHỈNH HÌNH NGHỆ AN

Abstract

Objective: To determine  efficacy and clinical benefits and safety of therapy with zoledro BFS in subjects with idiopathic osteoporosis. Method: 103 subjects with idiopathic and bone density Tscore ≤ - 2.5, received intravenous infusion of 5mg mixed in 100ml of 0.9% Nacl. Values of clinical examinations and laboratories were measured at baseline and at 3 day treatment. Results: After 1 year of treatment, bone density at the femoral neck (from - 3,312 to - 2,804) and the lumbar spine (from - 3.723 to - 3,263) p < 0.001. . After drug treatment causes undesirable effects such as: Fever accounted for 73.8% of patients, rheumatoid pain accounted for 70.9%. headache accounted for 37.9%, fake flu accounted for 60.2%. No adverse effects were observed after 1 year treatment in patients who received zoledro BFS. Concluson: Treatment with zoledro BFS 5mg/year sufficiently increase bone density levels without adverse effects in idiopathic osteoporosis patients.