KHẢO SÁT ĐỘC TÍNH CẤP VÀ ĐÁNH GIÁ TÁC DỤNG HẠ ĐƯỜNG HUYẾT CỦA CAO HOA TRÀ HOA VÀNG (Camellia flava) TRÊN MÔ HÌNH GÂY TĂNG ĐƯỜNG HUYẾT TRÊN CHUỘT NHẮT TRẮNG BẰNG ALLOXAN

Abstract

Objectives: Evaluating the acute toxicity and the hypoglycemic effect of Camellia flava flower extract on alloxan-induced hyperglycemia in mice. Subjects and Methods: Concentrated flower extract was prepared from Camellia flava (Pitard) Sealy, Theaceae provided by Truong Duong Trading Investment Joint Stock Company. The acute toxicity of flower extract was evaluated according to the guidance of decision 141/QĐ-K2ĐT. The hypoglycemic effect of flower extract was investigated in a female mice model of hyperglycemia with intravenous injection of alloxan. Mice after injection of alloxan 60 mg/kg with glycemic index ≥ 200 mg/dL were randomly divided into 7 groups, including:  sham group, disease group, positive control group, and 4 treatment groups with different doses of 0.22; 0.66; 1.09 and 2.19 (g/kg). Results: Groups of mice administrating flower extract at dose of 0.66; 1.09 and 2.19 (g/kg) had markedly hypoglycemic effects. Conclusion: Based on the results, it can be concluded that the extract has potential as a natural anti-diabetic agent. The Camellia flava flower extract observed to lower blood glucose levels in female mice with alloxan-induced hyperglycemia, with the best results seen in the groups treated with higher doses of the extract. Overall, these findings contribute to the growing interest in natural compounds as potential treatments for diabetes mellitus.