TIỂU ĐẢO BỆNH SINH CỦA HELICOBACTER PYLORI Ở UNG THƯ DẠ DÀY TẠI VIỆT NAM

Abstract

Background: Helicobacter pylori (H. pylori) infection is associated with some gastric diseases. cag-PAI gene is classified as one of the important virulence factors of H. pylori. Studies show that the frequency of cag-PAI accounts for 60-70% of all Western H. pylori strains and 100% for East Asian H. pylori strains. In Vietnam, the cag-PAI gene has not been studied much. Airm: Study on the role of cag-PAI in gastric pathology and the association of cag-PAI with gastric cancer in Vietnam. Subjects and methods: A cross-sectional study of 623 patients with H. pylori infection, including: Gastric cancer (n = 154), gastric ulcer (n = 129), duodenal  ulcer (n = 161) and chronic gastritis (n = 179). Diagnosis of gastric cancer and chronic gastritiss based on histopathology. Cag-PAI status was determined by Realtime-PCR technique. Results: The rate of cag-PAI (+) in gastric cancer (100%), significantly higher than cag-PAI (+) in patients with gastric ulcer (89.9%), duodenal ulcer (90%), chronic gastritis (78.2%). The rate of intact cag-PAI was significantly increased (p<0.05) in patients with gastric cancer (90.3%), gastric ulcer (88.4%), duodenal ulcer (87.6). %) compared with intact cag-PAI in chronic gastritis (76.5%). The percentage of intact cag-PAI was significantly increased (p < 0.05) in type III gastric cancer compared with intact cag-PAI in type I-II gastric cancer. The percentage of intact cag-PAI gene in patients with diffuse-mixed gastric cancer was significantly higher (p < 0.05) than intact cag-PAI in intestinal gastric cancer. Conclusion: The rate of intact cag-PAI is high in gastric cancer patients, closely related to endoscopic morphology and histopathology in gastric cancer patients in Vietnam.,.