TÌNH HÌNH ĐỀ KHÁNG KHÁNG SINH CỦA KLEBSIELLA PNEUMONIAE TẠI BỆNH VIỆN NGUYỄN TRI PHƯƠNG GIAI ĐOẠN 2019 - 2022

Abstract

Background: In the context of severe antibiotic resistance, the selection of antibiotics for the treatment of Klebsiella pneumoniae infection presents a challenge in clinical practice. Objective: Determine the prevalence and the susceptibility pattern of K. pneumoniae to several antibiotics from 2019 to 2022. Subjects and methods: K. pneumoniae strains isolated from 2019-2022 and their susceptibility to each antibiotic in the period of 2019-2022, were collected retrospectively from data in the laboratory of Nguyen Tri Phuong hospital. Differences in antibiotic susceptibility trends over the years were investigated using the Chi squared test. Results: Over a 4-year period, there were isolated 3045 K.pneumoniae bacteria from different samples. In which, the samples with the highest positive rate for K. pneumoniae were respiratory tract samples (46,2%), followed by pus/secretion fluid/Catheter samples (28,6%), urine samples (11,8%) and blood samples (10,6%). After 4 years, K.pneumoniae were still more than 50% sensitive with imipenem (70,1%), gentamicin (60,2%), tobramycin (59,9%), tetracycline (57,0%) and co-trimexazole (50,2%). The average rate of ESBL K. pneumoniae were 25,5% and the rate of multidrug-resistant K. pneumoniae were 60,3%. An decrease in antibiotic susceptibility of K.pneumoniae were observed statistically significant (p < 0,05) with most antibiotics types after four years. In which, K. pneumoniae showed the fastest trend of decreasing susceptibility to imipenem with statistical significance (p < 0,05), from 81,2% in 2019 to 60,9% in 2022. Conclusions: The antibiotic susceptibility rate of Klebsiella pneumoniae were low with majority tested antibiotics and had the rapidly decrease trend. Therefore, attention should be paid to strictly implementing the management and use of antibiotics with this bacterium.