KHẢO SÁT MỘT SỐ CHỈ SỐ SINH HỌC TRÊN DA BỆNH NHÂN VIÊM DA CƠ ĐỊA BẰNG MÁY PHÂN TÍCH LƯỢNG TỬ CỘNG HƯỞNG TỪ TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Background: Atopic dermatitis is a specific response of dermatitis to both endogenous and exogenous factors. Exogenous factors include: climate, environment, chemicals, ultraviolet light, cosmetics, food... Endogenous factors such as genetics, chronic digestive disorders, parasites irritation, metabolic disorders, endocrine dysfunction. It is a place that is a psychological and social burden for the patient and his/her family. The biological indicators on the skin of people with atopic dermatitis are different from those of normal people. Objective: Describe several skin biomarkers of patients with atopic dermatitis and determine the correlation between these biomarkers and clinic stages of the disease. Subjects and Methods: Case-control and cross-sectional descriptive studies were carried out on 30 patients with atopic dermatitis. Results: Quantitative analysis of several skin biomarkers on the skin of patients with atopic dermatitis by a quantum resonance magnetic analyzer showed that there was a disorder in some indexes (increase or decrease) compared to normal people. An increase of skin skin biomarkers including immune index of 63.3% (3.91 ± 1.62), free radicals of 53.3% (3.91 ± 1.83), skin moisture loss of 60.0% (4.94 ± 1.55), subcutaneous fat of 80.0% (25.42 ±  4.81), skin's horny layer 83.3% (2.30 ± 0.55), melanin 96.7% (0.60 ± 0.15). A decrease was detected with collagen of 90.0% (3.20 ± 0.89), skin elasticity of 50.9% (2.30 ± 0.69). The difference was statistically significant (with p<0.05,... and p<0.05). There was a positive correlation between the skin dilated capillary index and the clinical stages (corresponding to levels from mild,... to severe) in patients with atopic dermatitis (R = 0.44, p <0.05). Conclusions: There was an increase in skin biomarkers such as skin immunity, free radicals, skin moisture loss, subcutaneous fat, skin's horny layer, melanin and a decrease of collagen, skin elasticity. A positive correlation between the skin dilated capillary index and the clinical stages in patients with atopic dermatitis was showed.