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STUDY ON THE SITUATION AND SOME FACTORS RELATED TO BACTERIA PRODUCING CARBAPENEMASE IN PATIENTS WITH COMPLICATED URINARY TRACT INFECTIONS AT CAN THO CENTRAL GENERAL HOSPITAL IN 2021-2022
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Abstract
Background: Urinary tract infections complicated by multi-drug resistant bacteria have increased in recent times, especially carbapenemase producing bacteria. Objectives: 1). We aim to investigate the rate of carbapenemase producing bacteria in patients with complicated urinary tract infections and some related factors. 2). Investigation of antibiotic resistance status of carbapenemease producing bacteria at Can Tho Central General Hospital in 2021-2022. Subjects and methods:a descriptive cross-sectional study was performed on a total of 81 participants with complicated urinary tract infections inpatient treatment at CanTho Central General Hospital in 2021-2022. Data collection methods were clinical examination, bacteria identification, antibiogram and direct interviews. The Data were analyzed by SPSS 18.0. Results: the prevalence of carbapenemase producing bacteria in patients with complicated urinary tract infections was 28.4%, in which, Klebsiella spp accounted for the highest proportion with 56.5%, followed by E.coli accounting for 39.1%. There are three main factors associated with the prevalence of carbapenemase producing bacteria in patients with complicated urinary tract infections: recurrent urinary tract infection, previous antibiotic use and diabetes mellitus. It was found that the rate of carbapenemase producing bacteria was higher than the other group, with a statistical significance, p<0.05. Klebsiella spp produces carbapenemase which is resistant to most antibiotics, and is moderately sensitive to gentamicin and cotrim. E.coli produces carbapenemase, which is resistant to most antibiotics, and is moderately sensitive to amikacin and nitrofurantoin antibiotics. Conclusion: The rate of carbapenemase producing bacteria in patients is quite high, which the factors are related to recurrent urinary tract infection, previous antibiotic use, and diabetes mellitus.
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Keywords
: Complicated urinary tract infections, carbapenemase, related factors.
References
2. Lương Hồng Loan & Huỳnh Minh Tuấn (2020), ”Trực khuẩn gram âm tiết ESBL, AmpC, Carbapenemase và đề kháng kháng sinh tại bệnh viện Đại học tp. Hồ Chí Minh”, Y Học TP. Hồ Chí Minh, 24(2), tr. 223-229.
3. Nguyễn Chí Nguyễn, Nguyễn Dương Hiển, Lê Thuý An và cộng sự (2022), “Xác định tỷ lệ nhiễm và sự đề kháng kháng sinh của Klebsiella pneumonia sinh carbapenemase được phân lập từ các mẫu bệnh phẩm tại Bệnh viện Đa khoa Thành phố Cần Thơ và Bệnh viện Đa khoa Trung ương Cần Thơ năm 2021-2022”, Tạp chí Y Dược học Cần Thơ, 50, tr. 164-171.
4. Nguyễn Thị Thanh Tâm & Trần Thị Bích Hương (2015), “Đặc điểm lâm sàng và vi trùng học của nhiễm khuẩn đường tiết niệu phức tạp ơ người trưởng thành tại Bệnh viện Chợ Rẫy”, Y Học TP. Hồ Chí Minh, 19(4), tr. 458-465.
5. Abayneh, M., Tesfaw, G. & Abdissa, A. (2018), “Isolation of Extended-Spectrum β-lactamase- (ESBL-) Producing Escherichia coli and Klebsiella pneumoniae from Patients with Community-Onset Urinary Tract Infections in Jimma University Specialized Hospital, Southwest Ethiopia”, Canadian Journal of Infectious Diseases and Medical Microbiology, 2018, Id4846159.
6. Elrahem A.A, El-Mashad N, Elshaer M, et al, (2023), “Carbapenem Resistance in Gram-Negative Bacteria: A Hospital-Based Study in Egypt”, Medicina , 59, pp.285-295.
7. Eshetie S, Unakal C, Gelaw A, et al, (2015), “Multidrug resistant and carbapenemase producing Enterobacteriaceae among patients with urinary tract infection at referral Hospital, Northwest Ethiopia”, Antimicrobial Resistance and Infection Control, 4(1).
8. Ortega A, Saez D, Bautista V, et al (2016),“ Carbapenemase-producing Escherichia coli is becoming more prevalent in Spain mainly because of the polyclonal dissemination of OXA-48”, Journal of Antimicrobial Chemotherapy, 71(8), pp. 2131-2138.