XÁC ĐỊNH TỶ LỆ XUẤT HIỆN BIẾN CỐ BẤT LỢI VÀ MỘT SỐ YẾU TỐ LIÊN QUAN TRÊN BỆNH NHÂN LAO ĐA KHÁNG THUỐC TẠI BỆNH VIỆN PHỔI VĨNH LONG NĂM 2020-2022

Abstract

Objective: to determine the incidence of adverse events and some related factors in patiens with multi-resistant tuberculosis at Vinh Long Lung hospital from 2020 to 2022. Materials and methods: a descriptive study of a cluster of cases based on 131 outpatient records who started treatment for multidrug-resistant tuberculosis (MDR-TB) at Vinh Long Lung hospital, form January 2020 to December 2022. Data were collected and analyzed by using Excel 16 and SPSS 20.0 software, using Chi-square test with 95% confidence level. Results: out of a total of 131 outpatient medical records and 465 adverse events, the number of medical records with at least one adverse event was 115, accounting for 87,8%. In which, joint pain was the most common event with 51,9%, dizziness 50,4%, nausea or vomiting 49,6%, increased liver enzymes 46,6%, itching 42% besides some lessfrequent events were headache 3,8%, visual changes 7,6%, tinnitus or deafness 7,6%, prolongation of QT interval 7,6%. Several factors associated with the occurrence of adverse events were identified in the event of arthralgia and elevation of liver enzymes. For joint pain events, the relevant factors are the duration of treatment and drug content. In the event of elevation of liver enzymes, drug content, age and duration of treatment are related factors. Conclusion: the incidence of adverse events during the treatment of MDR-TB is still quite high, it is necessary to pay attention to related factors such as the use of drug content and duration of treatment for monitoring and limiting adverse events in out patients treated with MDR-TB.