ROLE OF SENTINAL LYMPH NODES BIOPSY USING TECHNETIUM-99M NANOCOLLOID IN PENILE CANCER
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Abstract
Objective: To evaluate the accuracy of sentinel lymph node biopsy by comparating SLN and regional lymph node metastasis in high risk penile cancer patients. Patients and methods: We described a series of 50 cases of cN0 T2-4 or Grad 3 penile cancer patients who underwent SLNB with Tc-99m. Results: The success rate of mapping was 94% by nodal region and 100% by patient. The sensitivity, specificity, accuracy, and false negative rate of Tc-99m SLNB were 85.7%, 100%, 98.9%, and 14.3%, respectively. Conclusion: Tc-99m guided SLNB may accurately predict the regional lymph node metastasis in penile cancer patients.
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References
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6. Whitman G, AlHalawani R, N K, R K. Sentinel Lymph Node Evaluation: What the Radiologist Needs to Know. Diagnostics. 2019;9(12):12.
7. Omorphos S, Saad Z, Kirkham A, et al. Zonal mapping of sentinel lymph nodes in penile cancer patients using fused SPECT/CT imaging and lymphoscintigraphy. Urologic oncology. 2018;36(12):530.e1 - 530.e6.
8. O'Brien JS, Teh J, Chen K, Kelly B, Chee J, Lawrentschuk N. Dynamic Sentinel Lymph Node Biopsy for Penile Cancer: Accuracy is in the Technique. Urology. Mar 11 2022;doi:10.1016/j.urology.2022.02.014
9. Kirrander P, Andren O, Windahl T. Dynamic sentinel node biopsy in penile cancer: initial experiences at a Swedish referral centre. BJU international. Mar 2013;111(3 Pt B):E48-53.
10. de Vries HM, Lee HJ, Lam W, et al. Clinicopathological predictors of finding additional inguinal lymph node metastases in penile cancer patients after positive dynamic sentinel node biopsy: a European multicentre evaluation. BJU international. Jul 2022;130(1):126-132. doi:10.1111/bju.15678
2. Flaig. T, Spiess PE. NCCN Guidlines Penile Cancer Version 1.2023. 2023.
3. Leijte JA, Kroon BK, Valdes Olmos RA, Nieweg OE, Horenblas S. Reliability and safety of current dynamic sentinel node biopsy for penile carcinoma. Eur Urol. Jul 2007;52(1):170-7. doi:10.1016/j.eururo.2007.01.107
4. Lee EWC, Issa A, Oliveira P, et al. High diagnostic accuracy of inguinal ultrasonography and fine-needle aspiration followed by dynamic sentinel lymph node biopsy in men with impalpable and palpable inguinal lymph nodes. BJU international. Sep 2022;130(3):331-336. doi:10.1111/bju.15700
5. Omorphos S, Saad Z, Arya M, et al. Feasibility of performing dynamic sentinel lymph node biopsy as a delayed procedure in penile cancer. World journal of urology. Mar 2016;34(3):329-35. doi:10.1007/s00345-015-1577-5
6. Whitman G, AlHalawani R, N K, R K. Sentinel Lymph Node Evaluation: What the Radiologist Needs to Know. Diagnostics. 2019;9(12):12.
7. Omorphos S, Saad Z, Kirkham A, et al. Zonal mapping of sentinel lymph nodes in penile cancer patients using fused SPECT/CT imaging and lymphoscintigraphy. Urologic oncology. 2018;36(12):530.e1 - 530.e6.
8. O'Brien JS, Teh J, Chen K, Kelly B, Chee J, Lawrentschuk N. Dynamic Sentinel Lymph Node Biopsy for Penile Cancer: Accuracy is in the Technique. Urology. Mar 11 2022;doi:10.1016/j.urology.2022.02.014
9. Kirrander P, Andren O, Windahl T. Dynamic sentinel node biopsy in penile cancer: initial experiences at a Swedish referral centre. BJU international. Mar 2013;111(3 Pt B):E48-53.
10. de Vries HM, Lee HJ, Lam W, et al. Clinicopathological predictors of finding additional inguinal lymph node metastases in penile cancer patients after positive dynamic sentinel node biopsy: a European multicentre evaluation. BJU international. Jul 2022;130(1):126-132. doi:10.1111/bju.15678