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EVALUATING THE INITIAL RESULTS OF YTTRIUM-90 RADIOEMBOLIZATION IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA
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Abstract
Hepatocellular carcinoma (HCC) is a common cancer with a high mortality rate in Viet Nam as well as in the world. Transarterial Chemoembolization plays a huge role in the treatment of HCC, in which Yttrium-90 radioembolization in selective is a new, highly effective method.
Purpose: To evaluate the initial safety and efficacy of Yttrium-90 Radioembolization for Hepatocellular Carcinoma. Materiels and methods: Prospective study of 25 patients diagnosed with HCC between January and February were treated with Yttrium-90 radioembolization. At 1 month and over 3 months, the patient was re-examined; tested by tumor marker and scanned for Computed with contrast. We take image information about tumor diameter, tumor contrast enhancement patterns. We assessed response to treatment according to modified Response Evaluation Criteria (mRECIST) and RECIST in Solid Tumors. Follow up the survival time of patients who have more than 3 months after treatment. Results: 25 patients (20 males, 5 females) with mean age 60 ± 9.8 years (from 38 years to 77 years), mean tumor diameter 55,76 ± 20,95mm, the median of tumor markers AFP, AFP-L3 and PIVKA-II is 7,5 ng/ml; 17% and 183 mAU/mL. At 1 month after the intervention, 17 patients re-examined, mean tumor diameter 46,5 ± 18,7mm; complete, partial, stable response, progressed according to RECIST is 0%; 35,3%; 58.8% and 5.9%; mRECIST 23,5%; 41,2%; 29,4% and 5,9% respectively. At the time of more than 3 months after the intervention, there were 13 patients re-examined with a mean tumor diameter 54,6 ± 24,8 mm. The response of complete, partial, stable, progressing according to RECIST is 0%; 53,8%; 15,4% and 30,8%, mRECIST is 30,8%; 23%; 15,4% and 30,8% respectively. There’s decrease value of tumor marker after treatment but has not significant. 19 patients with time to follow up ≥ 3 months, mean time survival is 18,4 ± 0,5 tháng. Conclusion: Yttrium-90 Radioembolization or Selective internal radiation therapy with Y-90 is an effective, safety method especially in large and unresectable hepatocellular carcinoma.
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Keywords
Radioembolization, Selective internal radiation therapy, Yttrium, hepatocellular carcinoma
References
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