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Date Published: 18/07/2023
Abstract Views: 196
Views PDF: 125
DOI: https://doi.org/10.51298/vmj.v528i1.5982
Issue
Vol. 528 No. 1 (2023)
Section
Các bài báo
How to Cite
Lê, N. A., Nguyễn, T. T., & Ngô, T. N. D. (2023). RESEARCH OF MMP-3 CONCENTRATIONS IN THE PLASMA OF PREECLAMPTIC PREGNANT WOMEN. Vietnam Medical Journal, 528(1). https://doi.org/10.51298/vmj.v528i1.5982

RESEARCH OF MMP-3 CONCENTRATIONS IN THE PLASMA OF PREECLAMPTIC PREGNANT WOMEN

Ngọc Anh Lê1,, Thanh Thúy Nguyễn2, Thị Ngọc Dung Ngô2
1 University of Medicine and Pharmacy, Hanoi National University
2 HMU

Main Article Content

Abstract

Objectives: To determine the concentration of MMP-3 in the plasma of physiologicallly pregnant women and pre-eclamptic ones, to detect the relation between MMP-3 concentration and some biochemical indicators of pre-eclamptic women. Subjects and methods: Two groups of pregnant women, including 60 physiologicallly pregnant women (control group) and 58 preeclamptic patients (patient group) from November 2021 to January 2023 at Hanoi Obstetrics and Gynecology Hospital. The concentration of MMP-3 was evaluated in both groups by the quantitative ELISA technique. Results: The average plasma concentrations of MMP-3 in the control and patient groups were 5.99 ± 3,73 and 62,33 ± 80,53 (ng/ml), respectively. The concentration of plasma MMP-3 of the patient group is 10 times higher than that of the control group, and this difference is statistically significant with 99,9% confidence (p<0,001). In addition, the concentration of MMP-3 is correlated with biochemical indicators including proteinuria, albumin, creatinine, urea, uric acid in preeclamptic women. Conclusion: The concentration of plasma MMP-3 of pregnant women with pre-eclampsia is 10 times higher than that of physiologicallly pregnant women

Article Details

Keywords

Pre-eclampsia, Matrix Metalloproteinase (MMP), MMP-3

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