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Date Published: 18/07/2023
Abstract Views: 350
Views PDF: 187
DOI: https://doi.org/10.51298/vmj.v528i1.5985
Issue
Vol. 528 No. 1 (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. T., Triệu , T. S., & Nguyễn, T. T. (2023). STUDY OF THE ASSOCIATION OF THROMBOTIC GENES FOR RECURRENT MISCARRIAGE AT VIETNAM MILITARY MEDICAL UNIVERSITY. Vietnam Medical Journal, 528(1). https://doi.org/10.51298/vmj.v528i1.5985

STUDY OF THE ASSOCIATION OF THROMBOTIC GENES FOR RECURRENT MISCARRIAGE AT VIETNAM MILITARY MEDICAL UNIVERSITY

Tổng Thống Nguyễn1,2,, Tiến Sang Triệu 3, Trọng Tuệ Nguyễn4
1 PH
2 Phenikaa university
3 Vietnam Military Medical Academy
4 HMU

Main Article Content

Abstract

Objectives: To study the role of thrombotic monogenic polymorphisms with the risk of consecutive miscarriages. Subjects and methods: Controlled cross-sectional description study on 200 women with a history of consecutive miscarriages and 100 women who had had normal childbirth at the Department of Biology and Medical Genetics, Viet Nam Military Medical University. Results: -675 4G/5G polymorphism of SERPINE1 gene is most common at 81.5% in the disease group, the second most common is FGB polymorphism: -455 G>A (accounting for 49.5% of the disease group), followed by other gene polymorphisms ITGA2(46%), ITGB3 (0.5%), F7(11%), F13A1 (1.5%), no cases of F2 polymorphism, FV Leiden were detected in the disease group. The combined occurrence rate of 2 FGB and SERPINE1 gene polymorphisms was 38.5% of the disease group, 26.8% of the control group; combination of 2 polymorphisms of genes F7, SERPINE1 of the control group was 6.4% and 2.2% respectively and in the combination of 3 gene polymorphisms F7, FGB, SERPINE 1, the proportion of the disease group accounted for 12.5% of the control group did not have any cases. Conclusion: The coordinated appearance of 2 genomic polymorphisms FGB, SERPINE1 or F7, SERPINE1 or the coordinated appearance of 3 polymorphisms F7, FGB, SERPINE 1 increases the risk of thrombosis in patients with consecutive miscarriages

Article Details

Keywords

Miscarriage, Stillbirth, Hypercoagulation gene, F2, FVL, F7, F13A1, FGB, ITGA2, ITGB3, SERPINE1

References

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