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Date Published: 18/07/2023
Abstract Views: 178
Views PDF: 114
DOI: https://doi.org/10.51298/vmj.v528i1.5996
Issue
Vol. 528 No. 1 (2023)
Section
Các bài báo
How to Cite
Trần, N. D., Đặng, T. T., & Phạm, V. T. (2023). RESEARCH ON HISTOLOGICAL CHARACTERISTICS AND THE SIGNIFICANCE OF AMACR IMMUNOHISTOCHEMICAL MARKERS IN PROSTATE CARCINOMA BIOPSIES. Vietnam Medical Journal, 528(1). https://doi.org/10.51298/vmj.v528i1.5996

RESEARCH ON HISTOLOGICAL CHARACTERISTICS AND THE SIGNIFICANCE OF AMACR IMMUNOHISTOCHEMICAL MARKERS IN PROSTATE CARCINOMA BIOPSIES

Ngọc Dũng Trần1,, Thái Trà Đặng1, Văn Thịnh Phạm1
1 103 Military Hospital

Main Article Content

Abstract

Objective: to evaluate the histopathological features of prostate carcinoma based on the Gleason scale and to investigate the diagnostic value of the AMACR marker. Subjects and methods: A retrospective analysis was conducted on 65 patients who received needle biopsies for prostate carcinoma at 103 Military Hospital between May 2019 and March 2022. Observe several characteristics related to age, total PSA concentration (tPSA), analysis of histopathological data, and the expression of the AMACR marker that has been obtained. Results: Most patients had high Gleason scores and the predominant histopathological structures were poorly differentiated, solid, ethmoid, or microcystic glands with perineural invasion being the most common. The AMACR marker demonstrated high sensitivity (92.3%) and specificity (76.9%) in diagnosis, although no significant correlation was observed between AMACR marker expression and Gleason score or total PSA levels. In conclusion, the Gleason score and the AMACR marker are valuable for diagnosis and prognosis in patients with prostate carcinoma.

Article Details

Keywords

: Prostate carcinoma, AMACR (P504S) marker, Gleason score.

References

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