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Date Published: 18/07/2023
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DOI: https://doi.org/10.51298/vmj.v528i1.6004
Issue
Vol. 528 No. 1 (2023)
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Nguyễn, N. A., & Nguyễn, D. H. (2023). THE COMBINED ROLE OF CONVENTIONAL, DIFFUSION AND PERFUSION MAGNETIC RESONANCE IMAGING IN PREOPERATIVE DIFFERENTIATION BETWEEN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA AND GLIOBLASTOMA. Vietnam Medical Journal, 528(1). https://doi.org/10.51298/vmj.v528i1.6004

THE COMBINED ROLE OF CONVENTIONAL, DIFFUSION AND PERFUSION MAGNETIC RESONANCE IMAGING IN PREOPERATIVE DIFFERENTIATION BETWEEN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA AND GLIOBLASTOMA

Ngọc Anh Nguyễn1, Duy Hùng Nguyễn1,2,
1 HMU
2 Viet Duc hospital

Main Article Content

Abstract

Objectives: The purpose of this study was to determine the efficacy of the combination of conventional, diffusion-weighted imaging (DWI) and dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) magnetic resonance imaging (MR imaging) in differentiate between primary central nervous system lymphoma (PCNSLs) and glioblastoma (GBMs). Methods  and  subject: Our retrospective study evaluated 45 patients with histologically confirmed brain tumors, including 18 PCNSLs and 27 GBMs. All patients underwent conventional MR imaging, DWI, DSC-PWI before surgical removal of the lesion or stereotactic biopsy. Three doctors approached four separate imaging groups: A (only conventional sequences), B (conventional and diffusion sequences), C (both conventional, diffusion and perfusion sequences). The kappa (κ) index was used to compare the histopathological diagnosis between groups. Results: Groups B had weak consistency (κ = 0,569), lower than groups A (κ = 0,808) and C (κ = 0,953). Groups C had almost prefect consistency with high sensitivity (94,4%), specificity (100%), positive predictive value (100%), negative predictive value (96,4%), and accuracy (ACC) (97,2%). Conclusions: Diffusion and perfusion sequences improve differentiate diagnosis between PCNSLs and GBMs compared to conventional sequences alone.

Article Details

Keywords

Conventional magnetic resonance imaging, Diffusion-weighted imaging, Perfusion-weighted imaging, Lymphoma, Glioblastoma

References

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