THE OUTCOME OF NATURAL CYCLE VERSUS ARTIFICIAL CYCLE IN FROZEN-THAWED EMBRYO TRANSFER

Thị Thu Hà Hoàng1, Tiến Tùng Dương1, Phương Anh Trần1, Khánh Linh Trần1, Anh Đào Nguyễn1, Ngọc Dung Lê1, Khang Sơn Nguyễn1,
1 HMU

Main Article Content

Abstract

Objectives: To evaluate outcomes in frozen-thawed embryo transfer, endometrial preparation with natural cycle and artificial cycle. Methods: Retrospective descriptive study with 86 cycles for frozen-thawed embryo transfer at Center of IVF and Tissue engineering, Hanoi Medical University Hospital from December 2022 to March 2023. Results: No significant differences were found between endometrial thickness on hCG injection day (natural cycle) and the last day of proliferative phase (artificial cycle). And no significant differences were found between the two groups with regard to the pregnancy rate (65.7% vs 68.6%). Conclusion: Both FET protocols are equally effective in terms of pregnancy outcomes but natural cycle is more favorable because it requires less medication, and has a significant cost reduction.

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References

The European IVF-Monitoring Consortium (EIM), for the European Society of Human Reproduction and Embryology (ESHRE), Kupka M.S. và cộng sự. (2016). Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE†. Human Reproduction, 31(2), 233–248.
2. Wilcox A.J., Baird D.D., và Weinberg C.R. (1999). Time of implantation of the conceptus and loss of pregnancy. N Engl J Med, 340(23), 1796–1799.
3. RESULTS - Frozen-Thawed Embryo Transfer - IVF-Worldwide. , accessed: 18/04/2023.
4. Sakkas D. và Gardner D.K. (2017). Evaluation of embryo quality Analysis of morphology and physiology. Textbook of Assisted Reproductive Techniques. 5, CRC Press.
5. Agha-Hosseini M., Hashemi L., Aleyasin A. và cộng sự. (2018). Natural cycle versus artificial cycle in frozen-thawed embryo transfer: A randomized prospective trial. Turk J Obstet Gynecol, 15(1), 12–17.
6. Mumusoglu S., Polat M., Ozbek I.Y. và cộng sự. (2021). Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review. Front Endocrinol (Lausanne), 12, 688237.
7. Cardenas Armas D.F., Peñarrubia J., Goday A. và cộng sự. (2019). Frozen-thawed blastocyst transfer in natural cycle increase implantation rates compared artificial cycle. Gynecol Endocrinol, 35(10), 873–877.
8. Pape J., Levy J., và von Wolff M. (2022). Early pregnancy complications after frozen-thawed embryo transfer in different cycle regimens: A retrospective cohort study. Eur J Obstet Gynecol Reprod Biol, 279, 102–106.
9. Pape J., Levy J., và von Wolff M. (2023). Hormone replacement cycles are associated with a higher risk of hypertensive disorders: Retrospective cohort study in singleton and twin pregnancies. BJOG, 130(4), 377–386.
10. Conrad K.P. (2011). Maternal vasodilation in pregnancy: the emerging role of relaxin. Am J Physiol Regul Integr Comp Physiol, 301(2), R267-275.