TẦN SUẤT TÁI PHÁT CỦA UNG THƯ VÒI TỬ CUNG TẠI BỆNH VIỆN TỪ DŨ

Abstract

Background: Primary fallopian tube carcinoma (PFTC) is a rare gynecological cancer, but its incidence is currently increasing. While the management is similar to epithelial ovarian cancer, PFTC has a higher risk of recurrence and poor prognosis. Therefore, it is important to identify the recurrence rate and prognostic factors associated with recurrence, which will help in providing patients with informed counseling and planning effective treatment strategies to improve clinical outcomes. Objective: This study aimed to determine the recurrence rate and related risk factors of PFTC at Tu Du Hospital. Methods: We conducted a retrospective cohort study of 47 patients with histopathological diagnosis of PFTC treated at Tu Du Hospital between January 2015 and July 2022. Results: The median follow–up period was 40 months (range, 7 – 96 months). Eight patients (17.0%) experienced recurrence. The cumulative recurrence rate of PFTC patients at 12 months was 4.4% (95% CI 1.12 – 16.45), at 24 months was 9.1% (95% CI 3.52 – 22.5), at 36 months was 14.9% (95% CI 6.92 – 30.41), at 48 months was 19.3% (95% CI 9.35 – 37.24), and at 60 months was 25.7% (95% CI 12.68 – 47.88). In the multivariate model, a higher recurrence rate was significantly associated with elevated pretreatment CA 125 level (< 35 U/mL vs ≥ 35 U/mL, HR 36.9, 95% CI 1.47 – 921.37), advanced FIGO stages (stage I–II vs stages III, HR 6.61, 95% CI 1.18 – 36.93), and suboptimal debulking surgery (residual disease ≤ 1 cm vs residual disease > 1cm, HR 7.52, 95% CI 1.47 – 38.49). Conclusion: The overall recurrence rate of PFTC patients at Tu Du Hospital was 17%. Elevated pretreatment CA 125 level, advanced FIGO stages, and suboptimal debulking surgery were main factors associated with recurrence