KHẢO SÁT THỰC TRẠNG SỬ DỤNG COLISTIN TẠI BỆNH VIỆN E

Abstract

Objectives: Investigate the characteristics of colistin use (indications, route of administration, dosage regimen, antibiotic combination) in clinical practice at E. Study population and methods: A descriptive cross-sectional study was performed on 61 medical records of patients using colistin from January 2021 to December 2021 at E hospital. Results: The ICU department administered colistin to most patients (83.6%), and pneumonia was the most common indication for colistin in the research (78.7%). Patients who have been prescribed colistin primarily for bacterial targets made up 88.5% of the total, whereas 11.5% of patients were assigned empirically. Colistin is most commonly used in conjunction with other antibiotics (96.8%), particularly carbapenem antibiotics. The loading dosage was administered to the majority of patients, with 13.1% (48/41) failing to do so in accordance with the instructions. The average daily dose of colistin was 4.85 ± 2.16  MIU/day, with a total dose of 72.57 ± 58.98 MIU. Conclusion: Loading dosage has not been employed in all departments. The dosing regimen should be customized depending on the C_ss target, and there should be more detailed information on how to determine C_ss at E hospital.