ĐẶC ĐIỂM LÂM SÀNG, VI SINH VÀ KẾT QUẢ ĐIỀU TRỊ VIÊM PHỔI CÓ SỬ DỤNG VANCOMYCIN Ở TRẺ EM TẠI BỆNH VIỆN SẢN NHI NGHỆ AN

Abstract

In Vietnam, pneumonia in children is the one of leading disease in terms of morbidity and mortality. Because of  an increase in  antibiotic-resistant bacteria, vancomycin is chosen as the main antibiotic for the treatment of severe infections caused by Gram-positive bacteria in children, especially Streptococcus pneumoniae.  Methods: It was a  descriptive cross-sectional study in 219  children with  pneumonia which was  treated with regimen included vancomycine at Nghe An Obstetrics and  Pediatrics Hospital. Results: The average age was 21.3 ± 26.6 months old, the age group from 13 to 60 months old accounted for the highest rate of 41.1%. The common symptoms of pneumonia were cough and fast breathing (>90%). 32.1% of cases were isolated the causes, with common cause was Streptococcus pneumoniae, accouting for 22.4%. After 7 days of treatment, the clinical symptoms improved remarkbly, with 5.9% with fever, 63.9% decreased in wheezing and 62.4% with non abnormal sound in  lung. The mortality rate was 0.8%.  2.7% of children using vancomycin had adverse effect, mainly red skin. Conclusion: Vancomycin is an effective antibiotic in the treatment of pneumonia. However, the  antibiotic use should be carefully because of  an increase in drug resistance.