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Date Published: 07/08/2023
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DOI: https://doi.org/10.51298/vmj.v528i2.6108
Issue
Vol. 528 No. 2 (2023)
Section
Các bài báo
How to Cite
Hồng, T. K. N., & Phạm, T. B. P. (2023). SURVEY OF THE FREQUENCY OF BROAD-SPECTRUM Β-LACTAMASE-PRODUCING BACTERIA AND THEIR ANTIBIOTIC RESISTANCE AT BINH DAN HOSPITAL. Vietnam Medical Journal, 528(2). https://doi.org/10.51298/vmj.v528i2.6108

SURVEY OF THE FREQUENCY OF BROAD-SPECTRUM Β-LACTAMASE-PRODUCING BACTERIA AND THEIR ANTIBIOTIC RESISTANCE AT BINH DAN HOSPITAL

Thị Khánh Ngân Hồng1,, Thị Bích Phượng Phạm2
1 Binh Dan hospital
2 Ho Chi Minh City Institute of Public Health

Main Article Content

Abstract

Background: Previously, infections caused by E. coli, K. pneumoniae and Enterobacter could be easily treated with 3rd and 4th generation cephalosporins, now, these bacteria are resistant to nearly 70% of antibiotics, caused by bacteria capable of secreting broad-spectrum β-lactams (ESBL). Therefore, we surveyed the frequency of broad-spectrum β-lactamase-producing bacteria to contribute to the diagnosis and treatment of infectious diseases. Objective: Survey of the frequency of broad-spectrum β-lactamase-producing bacteria and their antibiotic resistance at Binh Dan hospital. Methods: Descriptive cross-sectional study, all specimens which were isolated including blood, pus, urine, and fluids then chosen in this study in 2018 to January 2020. Method for detecting antibiotic-resistant bacteria at the Microbiology Department of Binh Dan Hospital and ESBL-producing bacteria by Kirby Bauer tests and Modified Double Disc Synergy Test and Combined Disk Test. Result: The ESBL-producing gram-negative bacilli was 32.03%. Among 13,403 gram-negative bacilli isolated from 17,226 positive samples, there were 4,293 cultures with ESBL-producing gram-negative bacilli, mainly urine and pus. When surveying ESBL-producing samples, we found that the top 3 bacteria causing nosocomial infection were E. coli (39.49%); K.pneumonia (31.64%); Klebsiella spp. (22.63%). In addition, we also recorded 3 cases of P. mirabilis; 1 case of Serratia spp (pus). 1 case of Enterobacter cloacae and 1 case of A. baumannii (sputum). The rate of resistance of ESBL-producing bacteria to Quinolone, Cephalosporin, Aminoglycoside antibiotics are >50%. Klebsiella spp. more resistant to most antibiotics in hospital use than E.coli, such as antibiotics in combination with beta lactamase inhibitors, for Klebsiella spp. >70%, E. coli <20%; carbapenem group of E. coli <37%, while Klebsiella spp. <57%. Conclusion: This results of the study form the basis for further surveillance studies and strengthen the management for the reasonable use of antibiotics

Article Details

Keywords

ESBL, β-lactamase-producing bacteria, antibiotic resistance.

References

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