Article Sidebar
Views PDF: 92
CLINICAL, RESULTS OF ADVANCED SURGERY AND RADIATION TREATMENT IN VIET DUC HOSPITAL
Main Article Content
Abstract
Total 52 patients medulloblastoma surgery in Viet Duc hospital with radiantion treatment, from 9/2016 to 9/2019. Result: Age from 02 - 43, mean age 13,19±10,47. Male/Female ratio = 1.6. Headache occurred in 84,6%. MRi, 15,4% in the cerebellar hemisphere, 84,6% in cerebella vermis. Tumor size mean 41,75 ± 7,6mm. The mean preoperative Karnofsky score was 69,04 ± 14,59. Gross Total Rececion (GTR) 73.1%, Near Total Resection (NTR) 25%. Patient were stable in 92.3%, severe was 7.7%. Only surgery: 45.8%, combined: 43.8% (chemotherapy: 9.5%, radiation therapy: 33.3%, chemotherapy - radiotherapy: 57.1%). Survival after surgery: 10.18±15.68 months. The mean survival time in group <18 years old: 31.08± 6.01 months, group > 18 years old 27.36±9.82 months.13 patients were alive at the end of the study (58.23±14, 61 months), the longest patient survival was 84 months. Conclution: Medulloblastoma is a grade 4 according to WHO. Tumor almost in vermis, large tumor size. The combination treatment group accounted: 43.8%. Average survival time after surgery: 10.11±5.68 months, longest patient survival: 84 months.
Article Details
Keywords
Medulloblastoma, Karnofsky, GOS, GTR, NTR.
References
2. System TWHOCoTotCN. World Health Organization Classification of Tumors of the Central Nervous System. Acta Neuropathologyca. Acta Neuropathologyca. 2016;Volume 131( Issue 6):803–820.
3. Bavle A, Parsons DW. From One to Many: Further Refinement of Medulloblastoma Subtypes Offers Promise for Personalized Therapy. Cancer Cell. Jun 12 2017;31(6):727-729.
4. Packer RJ, Zhou T, Holmes E, Vezina G, Gajjar A. Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961. Neuro Oncol. Jan 2013;15(1):97-103. doi: 10.1093/neuonc/nos267
5. Kumar LP, Deepa SF, Moinca I, Suresh P, Naidu KV. Medulloblastoma: A common pediatric tumor: Prognostic factors and predictors of outcome. Asian J Neurosurg. Jan-Mar 2015; 10(1):50. doi:10.4103/1793-5482.151516
6. Jenkin D, Shabanah MA, Shail EA, et al. Prognostic factors for medulloblastoma. International Journal of Radiation Oncology*Biology*Physics. 2000;47(3):573-584. doi:10.1016/s0360-3016(00)00431-4
7. Yu J, Zhao R, Shi W, Li H. Risk factors for the prognosis of pediatric medulloblastoma: a retrospective analysis of 40 cases. Clinics. 2017; 72(5):294-304. doi:10.6061/clinics/2017(05)07
8. Christopherson KM, Bradley JA, Rotondo RL, et al. Local control in non-metastatic medulloblastoma. Acta Oncol. Sep 2014; 53(9): 1151-7. doi:10.3109/0284186x.2014.932434
9. Vinchon M, Leblond P. Medulloblastoma: Clinical presentation. Neurochirurgie. Feb 2021; 67(1):23-27. doi:10.1016/j.neuchi.2019.04.006
10. T V Học. Nghiên cứu đặc điểm lâm sàng, mô bệnh học và đánh giá kết quả điều trị u tiểu não ở trẻ em tại Bệnh viện Nhi Trung ương. Luận án tiến sĩ y học, Đại học Y Hà Nội. 2016;