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CHANGES IN ANGIOPOIETIN-1 AND ANGIOPOIETIN-2 CONCENTRATIONS IN PATIENTS WITH SEPSIS AT VIETTIEP FRIENDSHIP HOSPITAL FROM 2018 - 2020
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Abstract
Objectives: Analyze the predictive value of Angiopoietin-2 plasma concentration in sepsis patients at Vietnam Friendship Hospital from 2018 to 2020. Methods: A prospective descriptive study on 105 patients sepsis at Viet Tiep Friendship Hospital from 2018 - 2020. Result: Mean age was 66.2 ± 16.3; the age group over 60 accounted 68.6%; men accounted for 54.3%. The Ang-2 concentration at the time of diagnosis (T0) had a moderate predictive value of mortality in patients with sepsis with the area under the ROC curve (AUC) = 0.68 (0.53-0.83). with p<0.05. Levels of Ang-2 plasma concentration had an equal predictive value of mortality compare to that of Lactate and SOFA scores at time T0 with AUC of 0.67 (95%CI 0.52-0.81, p < 0,05) and 0.66 (95%CI 0.52-0.8, p < 0.05), respectively. Pairing the Ang-2 plasma concentration index at T0 with the SOFA and APACHE II severity rating scales increased the predictive value of mortality, the areas under the ROC curve increased compared to only had Ang-2 concentration alone, with an area under the ROC curve of 0.72 (95% CI: 0.59-0.87, p<0.05) and 0.69 (95%CI 0,54-0.85, p<0.05), respectively. Conclusion: Angiopoietin-2 plasma concentration may serve as an additional biomarker for the prognosis of sepsis and septic shock.
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Keywords
Sepsis, predictive value, angiopoietin-2.
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