MÔ TẢ ĐẶC ĐIỂM VI SINH TRÊN CÁC BỆNH NHÂN ĐƯỢC CHỈ ĐỊNH COLISTIN TẠI BỆNH VIỆN E

Abstract

Objectives: Investigate the Characterization of bacteria and the colistin resistance of Gram-negative bacteria isolated at E hospital. Study  population  and  methods: A descriptive cross-sectional study was performed on 61 medical records of patients using colistin from January 2021 to December 2021 at E hospital. Results: The patients were mainly treated in the intensive care unit (83.6%) with the main infectious disease being pneumonia (78.7%). The samples taken were quite diverse, mainly sputum, blood and urine. The most common bacterial isolates associated with the indication for colistin were A. baumannii and P. aeruginosa, accounting for 57.1%% and 28.6%, respectively. Multi-resistant bacteria (MDR) accounted for the majority with the rate of 59.7%., A. baumannii was the most resistant strain (56.5%). There were 11 strains (8 strains of A. baumannii, 2 strains of P. aeruginosa and 1 strain of i that were completely resistant to antibiotics.Four strains of bacteria were analyzed with colistin A. baumannii, P. aeruginosa, K. pneumoniae and C. freundii has the ratio S, I, R respectively: 23.3%, 73.3%, 6.7%, of which, only 9 samples were returned with MIC results: A.baumannii had fluctuating MIC from: 0.025 to 0.5 µg/ml. Conclusion: Colistin is one of the last options for multi-resistant Gram-negative bacteria. In this study, strains of bacteria resistant to colistin appeared. Therefore, it is necessary to consider the choice of using colistin as well as optimizing the dose of colistin to prevent the emergence of resistant strains of bacteria.