Article Sidebar
Views pdf: 136
RESULTS SURGICAL TREATMENT FOR SOLID PSEUDOPAPILARY NEOPLASMS OF PANCREAS IN CHILREN AT VIETNAM NATIONAL CHILDREN’S HOSPITAL: A REPORT OF 15 CASES
Main Article Content
Abstract
Objectives: Evalute results surgical treatment for solid pseudopapillary neoplasm of the pancreas in children at Vietnam National Children’s Hospital. Subjects and methods: A case-series study on 15 patients diagnosed with SPN who were operated at Vietnam National Children’s Hospital from January 2021 to December 2022. Results: The mean age of SPN was 10,8 ± 2 years old (range, 8 – 15 years). Among 15 patients; 14 (93.3%) were females. The most common symptom was abdominal pain (86,6%), palpable tumor (6,6%), no symptom (6,6%). The abdominal CT signs included the tumor in head of pancreas (46,7%) and body and tail of the pancreas (53.3%), mixed density structure 13/15 (86,7%) and mean diameters of SPN was 4,7 ± 0,5cm (range, 2.3 – 9.7cm). All of our patients had been through open surgery, in which: pancreaticoduodenectomy was done in 1 case (6,6%), pancreatectomy with preservation of the duoenum in 6/15 cases (40%), central pancreatectomy in 3/15 cases (20%), pancreatectomy combined with splenectomy 4/15 cases (26,6%) and pancreatectomy with preservation of the spleen surgery was held in 1 case (6,6%). 7/15 of patients (46,7%) had IHC to confirm SPN. All of them took follow-up examination after the surgery, there was no dead or sign of tumor relapse. Conclusion: SPN is a rare exocrine pancreatic tumor. The cancer grade is usually low, the rate of spreading or metastasis and recurrence is low, so for children, curative surgery with maximal preservation of organ function is the safe and effective treatment.
Article Details
Keywords
Solid pseudopapilaty neoplasms of pancreas, children.
References
2. Wu, J., Mao, Y., Jiang, Y., Song, Y., Yu, P., Sun, S., Li, S.: Sex differences in solid pseudopapillary neoplasm of the pancreas: A population-based study. Cancer Med. 9, 6030–6041 (2020). https://doi.org/10.1002/cam4.3180
3. Bochis, O.V., Bota, M., Mihut, E., Buiga, R., Hazbei, D.S., Irimie, A.: Solid pseudopapillary tumor of the pancreas: clinical-pathological features and management of 13 cases. Clujul Med. 1957. 90, 171–178 (2017). https://doi.org/10.15386/cjmed-672
4. Kumar, N.A.N., Bhandare, M.S., Chaudhari, V., Sasi, S.P., Shrikhande, S.V.: Analysis of 50 cases of solid pseudopapillary tumor of pancreas: Aggressive surgical resection provides excellent outcomes. Eur. J. Surg. Oncol. J. Eur. Soc. Surg. Oncol. Br. Assoc. Surg. Oncol. 45, 187–191 (2019). https://doi.org/10.1016/j.ejso.2018.08.027
5. Shen, Y., Wang, Z., Zhu, J., Chen, Y., Gu, W., Liu, Q.: α-Methylacyl-CoA racemase (P504S) is a useful marker for the differential diagnosis of solid pseudopapillary neoplasm of the pancreas. Ann. Diagn. Pathol. 18, 146–150 (2014). https:// doi.org/10.1016/j.anndiagpath.2014.02.006
6. You, L., Yang, F., Fu, D.-L.: Prediction of malignancy and adverse outcome of solid pseudopapillary tumor of the pancreas. World J. Gastrointest. Oncol. 10, 184–193 (2018). https://doi.org/10.4251/wjgo.v10.i7.184
7. Lubezky, N., Papoulas, M., Lessing, Y., Gitstein, G., Brazowski, E., Nachmany, I., Lahat, G., Goykhman, Y., Ben-Yehuda, A., Nakache, R., Klausner, J.M.: Solid pseudopapillary neoplasm of the pancreas: Management and long-term outcome. Eur. J. Surg. Oncol. J. Eur. Soc. Surg. Oncol. Br. Assoc. Surg. Oncol. 43, 1056–1060 (2017). https://doi.org/10.1016/j.ejso.2017.02.001
8. Beger, H.G., Witte, C., Krautzberger, W., Bittner, R.: [Experiences with duodenum-sparing pancreas head resection in chronic pancreatitis]. Chir. Z. Alle Geb. Oper. Medizen. 51, 303–307 (1980)