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Date Published: 31/07/2021
Abstract Views: 346
Views PDF: 162
DOI: https://doi.org/10.51298/vmj.v502i2.625
Issue
Vol. 502 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Thái Hoà, N. ., & Thanh Huyền, M. . (2021). TREATMENT RESULTS OF PEMETREXED-CARBOPLATIN REGIMEN AS SECOND-LINE FOR NON–SMALL CELL LUNG CANCER AFTER EGFR TKIs ACCQUIRED RESISTANCE. Vietnam Medical Journal, 502(2). https://doi.org/10.51298/vmj.v502i2.625

TREATMENT RESULTS OF PEMETREXED-CARBOPLATIN REGIMEN AS SECOND-LINE FOR NON–SMALL CELL LUNG CANCER AFTER EGFR TKIs ACCQUIRED RESISTANCE

Nguyễn Thị Thái Hoà, Mai Thanh Huyền

Main Article Content

Abstract

Objective: To evaluate the treatment results of Pemetrexed - Carboplatin regimen in patients with non-small cell lung cancer after Tyrosin Kinase inhibitor accquired resistance. Objects and methods: Retrospective of 46 patients after accquired resistance to EGFR TKIs, on Pemetrexed - Carboplatin regimen, with longitudinal follow-up. Results: Rate of objective response 50%; complete response 0%; disease control 78.3%. Prognostic factors for poorer response: performance status PS1, stage IV, CNS metastasis. Median progression - free survival: 4 months. Conclusion: Pemetrexed - Carboplatin regimen is an appropriate treatment choice for patients with non-small cell lung cancer after resistance to Tyrosin Kinase inhibitors.

Article Details

Keywords

Non-small cell Lung cancer, accquired resistance, response rate, progression- free survival

References

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