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RESEARCH OF FACTORS RELATED TO MORTALITY IN PATIENTS WITH METHANOL POISONING
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Abstract
Objective: to evaluate the factors related to fatal outcome in the patients with acute methanol poisoning. Subjects and Methods: A analysis observational study included 107 patients with methanol intoxication treated at Poison Control Center of Bach Mai Hospital from January 2016 to July 2019. Results: The study patients were mainly male (97.2%), the mean age were 47.6 ± 12.6 years and mainly in the age group of 40-59 (65.4%). Methanol poisoning is severe with high mortality rate (41.1%). Some main factors related to death in patients with acute methanol poisoning: delay admission (more than 24 hours from ingestion to hoospital admission) (OR 1.04; p <0.05); deep coma on admission (OR 0.24; p <0.05); severe metabolic acidosis pH <7.0 (OR 0.22; p<0.05; acute renal failure (OR 5.13; p <0.05); hyperglycemia (OR 13.28; p <0,05); Hypotension requires vasopressors (OR 0.019; p <0.01). Conlusion: The study showed the association between some clinical, laboratory and therapeutic predictors with mortality in patients with acute methanol poisoning.
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Keywords
methanol poisoning, mortality, predictors
References
2. Phạm Như Quỳnh, Lê Đình Tùng, Hà Trần Hưng (2017). Hiệu quả của thẩm tách máu kéo dài trong điều trị bệnh nhân ngộ độc cấp methanol. Tạp chí Sinh lý học Việt Nam, 21(3), 13-20.
3. Chang S.T., Wang Y.T., Hou Y.C., et al (2019). Acute kidney injury and the risk of mortality in patients with methanol intoxication. BMC Nephrol 20: 205.
4. Coulter C.V., Farquhar S.E., McSherry C.M., et al (2011). Methanol and ethylene glycol acute poisonings - predictors of mortality. Clin Toxicol (Phila); 49(10): 900-6.
5. Hassanian-Moghaddam H., Pajoumand A., Dadgar S.M., et al (2007). Prognostic factors in methanol poisoning. Human & Experimental Toxicology, 26: 583–586.
6. Hovda K.E.., Hunderi O.H., Tafjord A..B, et al (2005). Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs. J Intern Med, 258(2), 181-90.
7. Lee C.Y., Chang L.K., Lin J.L, et al (2014). Risk factors for mortality in Asian Taiwanese patients with methanol poisoning. Ther Clin Risk Manag, 10, 61-7.
8. Paasma R., Hovda K.E., Hassanian-Moghaddam H., et al (2012). Risk factors related to poor outcome after methanol poisoning and the relation between outcome and antidotes – a multicenter study. Informa Healthcare USA, Inc, Clinical Toxicology, 50, 823–831.
9. Sanaei-Zadeh H., Esfeh S.K., Zamani N., et al (2011). Hyperglycemia is a strong prognostic factor of lethality in methanol poisoning. J Med Toxicol, 7(3), 189-94.