RESEARCH ON SOME BIOCHEMICAL CHANGES AFTER SURGERY FOR TREATMENT OF HYPERPARATHYROIDISM

Ánh Ngọc Nguyễn1,, Ngọc Lương Trần1, Văn Viện Mai2
1 Endocrine central hospital
2 Military Central Hospital 108

Main Article Content

Abstract

Objectives: To evaluate some biochemical changes after surgery to treat hyperparathyroidism and some associated complications such as hypocalcemia, starvation bone syndrome, recurrent hyperparathyroidism. Subjects and methods: A prospective, cross-sectional study of 244 patients diagnosed with hyperparathyroidism and treated by surgery at the National Hospital of Endocrinology from 3/2016 to 9/2019. Results: A total of 244 patients including 38 primary HPT (pHPT), 141 secondary HPT (sHPT), 65 tertiary HPT (tHPT) were diagnosed and treated by surgery. The concentration of PTH, total calcium and ionic calcium in the blood decreased rapidly after surgery in all cases. Postoperative hypocalcemia: pHPT: 10.5%, sHPT: 64.5% and tHPT: 69.2%. Hunger bone syndrome: pHPT: 2.6%, sHPT: 46.1%, tHPT: 46.2%. Recurrent hyperparathyroidism after parathyroidectomy: pHPT: 0%, sHPT: 9.2%, tHPT: 6.2%. Conclusion: After parathyroidectomy, the biochemical indicators were improved. Postoperative hypocalcemia is uncommon in pHPT, and is common in sHPT and tHPT. Hungry bone syndrome is common in sHPT and tHPT. Recurrent hyperparathyroidism after parathyroidectomy is only seen in sHPT and tHPT

Article Details

References

Norman parathyroid center (2013). Hyperparathyroidism - Disease of the parathyroid glands – Parathyroid.com.
2. Barbara Austin (2017). Primary Hyperparathyroidism A Case-based Review. Clinician Reviews.
3. Witteveen J.E, Thiel S.V et al (2013). Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature. European Journal of Endocrinology, 168, R45-R53.
4. Angela A Khan, Yasmin Khatun, Abigail Walker et al (2020). Role of Intraoperative PTH Monitoring and Surgical Approach in Primary Hyperparathyroidism. https://pubmed. ncbi.nlm.nih.gov/26468374. Journal, 22, 122-124.
5. Vũ Trung Lương. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và đánh giá kết quả cắt u tuyến cận giáp tại khoa Tai Mũi Họng bệnh viện Bạch Mai. Y học thực hành (893) - số 11/2013, 2013: p. 81-84.
6. Prasarttong-Osoth P, Wathanaoran P, Imruetaicharoenchoke W et al (2012). Primary hyperparathyroidism: 11-year experience in a single institute in Thailand. International Journal of Endocrinology, 1-4.
7. Bhansali A, Masoodi S.R, Reddy S et al (2005). Primary hyperparathyroidism in north India: a description of 52 cases. Annals of Saudi Medicine, 25(1), 1-7.
8. Alexander Shifrin (2020). Atlas of Parathyroid Surgery – p: 173-185.