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CHARACTERISTIC OF THE rs1333040 POLYMORPHISM OF THE ANRIL GENE IN HUMAN AMERICAN MISCELLANEOUS AT THE HOAN MY CUU LONG GENERAL HOSPITAL
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Abstract
Background: Single nucleotide polymorphism rs1333040 ANRIL gene is known to be associated with some clinical and subclinical features in patients with acute myocardial infarction. Objectives: To investigate the characteristics of rs1333040 ANRIL gene polymorphism in patients with acute myocardial infarction at Hoan My Cuu Long General Hospital. Materials and methods: a cross-sectional descriptive study with analysis on 80 patients with acute myocardial infarction diagnosed and treated at Hoan My Cuu Long General Hospital. Results: The study subjects had an average age of 66.8±10.47; Men accounted for 58.8%. Hypertension (83.8%) and dyslipidemia (80.0%) were the most common coronary heart disease risk factors. 55.0% of patients were in the non-ST-segment elevation acute myocardial infarction group. Characteristics of polymorphism rs1333040: genotype TT, TC, CC were 58.8%, 33.7%, 7.5%, respectively, T allele with 75.6%, C allele 24.4%. The study had not recorded a statistically significant difference between the rates of three genotypes TT, TC and CC with the following characteristics: age, sex, clinical forms and some cardiovascular risk factors. Conclusion: Surveying polymorphism rs1333040 in 80 patients with acute myocardial infarction at Hoan My Cuu Long General Hospital recorded the highest percentage of TT genotype and T allele. Further studies with larger numbers of patients are needed to determine the association of polymorphism rates with cardiovascular risks.
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Keywords
: Acute myocardial infarction, ANRIL, rs1333040.
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