KHẢO SÁT NỒNG ĐỘ TNF - ALPHA, IL-6 HUYẾT TƯƠNG Ở BỆNH NHÂN VIÊM THẬN LUPUS

Abstract

Objectives: To investigate plasma levels of TNF-alpha, IL-6, and its correlation between TNF-alpha, IL-6 levels with some characteristics of kidney injury in pediatric lupus nephritis. Patients and Methods: Cross-sectional descriptive study compared with the healthy control group. 117 children (87 patients with lupus nephritis and 30 healthy control children) from 9/2019 to 9/2022 at the National Children's Hospital. Results: Mean age of the patient group was 10.94 ± 2.1; 81.6% were female. The median level of plasma TNF-alpha was 4.73 ng/L. It was higher in the disease group than in the healthy control group (3.54 ng/L), p< 0,001. there was a 47.1% increase in TNF-alpha level in LN compared with the control group. The median level of plasma IL6 was 3.19 ng/L, higher than the control group (1.14 ng/L), p < 0.001. the proportion of children with increased IL-6 levels compared to the control group was 56.3%. Elevated levels of TNF-alpha and IL-6 were associated with disease severity through the SLEDAI score. The group of severe and very severe pediatric patients had higher levels of TNF-alpha, IL-6, and the rate of increase level than the group of patients with mild and moderate disease, p<0.001. Conclusions: Elevated plasma levels of TNF-alpha and IL-6 are relatively common and are associated with the severity of pediatric lupus nephritis.