ĐÁNH GIÁ TÌNH TRẠNG QUÁ PHÁT VI KHUẨN RUỘT NON Ở BỆNH NHÂN HỘI CHỨNG RUỘT KÍCH THÍCH THỂ TIÊU CHẢY BẰNG TEST THỞ HYDROGEN

Abstract

Introduction: The hydrogen breathing test (HBT) is useful for diagnosing small intestinal bacterial overgrowth (SIBO) and carbohydrate intolerance, especially in patients with irritable bowel syndrome (IBS) because of many similar symptoms. In Vietnam, there is not much data on the relationship between SIBO and IBS. Objectives: This study evaluated condition of SIBO and its relationship to clinical symptoms, quality of life in patients with irritable bowel syndrome with diarrhea (IBS-D) by hydrogen breath test (HBT). Methods: A cross-sectional study was conducted on 30 patients aged ≥ 18 years old, diagnosed with IBS-D according to the ROME IV criteria, and diagnosed with SIBO by HBT at the Institute of Gastroenterology and Hepatology between January 2022 and April 2023. Results: The prevalence of SIBO in IBD-D patients was 70%. The baseline hydrogen concentration and the average hydrogen concentration at 15, 30, 45 minutes concentration in the SIBO group were statistically significant higher in compared to the non-SIBO group (p<0.05). There was no differences in age, gender, BMI, frequency of loose stools, and severity of IBS between the two groups. The SIBO group had more abdominal distension and poorer quality of life compared to the non-SIBO group, the difference was statistically significant (p<0.05). Conclusion: SIBO is quite common among IBS-D patients with the prevalence of 70%. The SIBO group had more abdominal distention and poorer quality of life compared to the non-SIBO group.