PROGNOSTIC FACTORS OF COVID-19 PATIENTS UNDERGOING ECMO AT THE NATIONAL HOSPITAL FOR TROPICAL DISEASES

Phú Khiêm Đồng1,, Đình Phú Vũ1, Văn Dương Đặng1, Duy Thành Đoàn1, Quốc Phong Đỗ2
1 Central Hospital for Tropical Diseases
2 E hospital

Main Article Content

Abstract

Objective: To assess the prognostic factors of COVID-19 patients undergoing ECMO at the National Hospital of Tropical Diseases. Methods: Descriptive observational study of COVID-19 patients receiving ECMO, conducted from March 2020 to March 2022. Results: A total of 58 eligible patients were included, with males accounting for 50% and a mean age of 48±16 years. Among them, 72.4% had underlying comorbidities. Prior to ECMO initiation, the mean Murray score and SOFA score were 3.5 and 6, respectively. Treatment outcomes showed that 28 patients (48.3%) were discharged in stable condition. Cardiovascular disease, diabetes, bacterial coinfection, and severe bleeding, thrombocytopenia, elevated blood bilirubin complications, and septic shock were risk factors associated with increased mortality. Pregnancy and the use of Remdesivir were protective factors associated with reduced mortality. Conclusion: This is the first report in Vietnam to date on the prognostic factors of COVID-19 patients undergoing ECMO intervention. The prognostic factors in this study are similar to most reports in the region and worldwide.

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References

Badulak J, et al. (2021). Extracorporeal Membrane Oxygenation for COVID-19: Updated 2021 Guidelines from the Extracorporeal Life Support Organization. ASAIO J 2021, 67(5):485-495.
2. Bộ y tế. (2020). Hướng dẫn chẩn đoán và điều trị COVID19 do chủng vi rút Corona mới (SARS-COV-2). Quyết định số 1344-QĐ-BYT Ngày 25 tháng 3 năm 2020 của Bộ Trưởng Bộ Y Tế
3. Ling RR, et al. (2022). Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis. Crit Care, 26(1):147.
4. Barbaro RP, et al. (2021). Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international Extracorporeal Life Support Organization Registry. Lancet, 398(10307):1230-1238.
5. Tran A, et al. (2023). Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Lancet Respir Med, 11(3):235-244.
6. O'Neil ER, et al. (2022). Pregnant and Peripartum Women with COVID-19 Have High Survival with Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis. Am J Respir Crit Care Med, 205(2):248-250.
7. Jin Y, Zhang Y, Liu J. (2022). Ischemic stroke and intracranial hemorrhage in extracorporeal membrane oxygenation for COVID-19: A systematic review and meta-analysis. Perfusion:2676591221130886.
8. Jin Y, Zhang Y, Liu J, Zhou Z. (2023). Thrombosis and bleeding in patients with COVID-19 requiring extracorporeal membrane oxygenation: a systematic review and meta-analysis. Res Pract Thromb Haemost, 7(2):100103.