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Date Published: 30/08/2023
Abstract Views: 222
Views pdf: 153
DOI: https://doi.org/10.51298/vmj.v529i1B.6367
Issue
Vol. 529 No. 1B (2023)
Section
Các bài báo
How to Cite
Dương, H. N., Nguyễn, X. T., Vũ, X. N., & Lương, C. T. (2023). RESEARCH ON THE RELATIONSHIPS BETWEEN ALTERATION OF SERUM sST2 CONCENTRATION AND SOME CLINICAL FEATURES IN PATIENTS WITH CHRONIC HEART FAILURE AFTER A TREATMENT. Vietnam Medical Journal, 529(1B). https://doi.org/10.51298/vmj.v529i1B.6367

RESEARCH ON THE RELATIONSHIPS BETWEEN ALTERATION OF SERUM sST2 CONCENTRATION AND SOME CLINICAL FEATURES IN PATIENTS WITH CHRONIC HEART FAILURE AFTER A TREATMENT

Hồng Niên Dương1, Xuân Tiện Nguyễn2, Xuân Nghĩa Vũ3, Công Thức Lương4,
1 Hospital 198, Ministry of Public Security
2 Military Institute of Preventive Medicine
3 108 Military Central Hospital
4 103 Military Hospital

Main Article Content

Abstract

Objectives: To evaluate the relationship between change in serum sST2 concentration and some clinical symtomps in patients with chronic heart failure (HF) after a course of treatment. Subjects and methods: a total of 116 patients diagnosed as chronic HF being treated at Military Hospital 103 and Hospital 198 were collected from November 2019 to October 2022. Serum sST2 level was quantified by ELISA. The pearson rank correlation coefficient or the Independent Samples T-Test was used to assess the relationships between the log (sST2) and the patient's clinical symptoms. Results: After a treatment, the mean of log (sST2) was significantly decreased as compared with before treatment. Decreased sST2, NT-proBNP levels and increased left ventricular systolic ejection fraction (LVEF) after the treatment was found. The decrease in sST2 concentration after the treatment was positive and significant correlation with the improvement of the patient's NYHA class. However, the decrease in NT-proBNP concentration or the increase in LVEF after the treatment was not correlated with the improvement of the NYHA class. Conclusion: The alteration of serum sST2 concentration after a course of treatment was related to the change in clinical symptoms in patients with chronic HF.

Article Details

Keywords

sST2, chronic heart failure, NYHA, LVEF

References

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