MỘT SỐ YẾU TỐ LIÊN QUAN TỚI KẾT QUẢ ĐIỀU TRỊ NHỒI MÁU NÃO CẤP HỆ TUẦN HOÀN TRƯỚC BẰNG ALTEPLASE KẾT HỢP LẤY HUYẾT KHỐI CƠ HỌC

Abstract

Target: To determine the rate of good clinical outcome, mRS 0-2 at day 90th, and some factors associated with patients’ acute ischemic stroke due to large artery occlusion of the anterior cerebral circulation have been treated with an Alteplase dose of 0.9mg/kg combined with mechanical thrombectomy at Bach Mai Hospital. Methods: Observational study design, and analysis of 35 patients with acute ischemic stroke within a 4.5-hour window due to large artery occlusion of the anterior cerebral circulation with an Alteplase dose of 0.9mg/kg combined with mechanical thrombectomy at Bach Mai Hospital from 2018 to 2020. Results: The study recruited 35 patients; men accounted for 59.1%. The group with good clinical outcomes, mRS 0-2 days 90, accounted for 22/35 (62.9%). Some factors associated with good clinical outcomes are age (OR 0.91; 95%CI 0.82-0.98; p=0.04), admitted NIHSS score (OR 0.95; 95 % CI 0.92-0.98; p=0.02), number of retrieval attempts (OR 0.62; 95%CI 0.55-0.68; p=0.03). Conclusions: The rate of good clinical outcomes for patients with acute ischemic stroke of the anterior cerebral circulation who have been bridge treated with good clinical outcomes was 62.9% and some associated factors were age, baseline NIHSS score, and number of retrieval attempts.