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THE EFFECTIVENESS OF CETUXIMAB COMBINED WITH CHEMOTHERAPY IN FIRST - LINE TREATMENT FOR METASTATIC, RECURENCED COLORECTAL CANCER
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Abstract
The study aimed to evaluate the effectiveness and side effects of cetuximab combined with chemotherapy in first-line treatment for patients having metastatic or recurenced RAS wild-type colorectal cancer. Subjects and methods: A retrospective, descriptive study on 50 patients with metastatic or recurenced RAS wild-type colorectal cancer treated by cetuximab in combination with mFOLFOX6 or FOLFIRI in K hospital from 1/2017 to 3/2023. Results: The overall response rate (ORR) was 80%, the mean progression-free survival (PFS) was 15,1 months. The most common side effect was dermatitis acneiform (88%), in which grade 1-2 accounted for 84%; the nail changes occurred in 64% of the patients; the other side effects were mainly mild (grade 1-2). Conclusion: First-line cetuximab combined with chemotherapy resulted in high response rate and tolerable toxicity, which can be optimal treatment for patients with metastatic or recurenced RAS wild-type colorectal cancer.
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Keywords
: Cetuximab, metastatic colorectal cancer, RAS wild-type, first - line treatment.
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