GENETIC ABNORMALITIES OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED IN THE NATIONAL INSTITUE OF HEMATOLOGY AND BLOOD TRANSFUSION

Quang Hưng Vũ1,, Quốc Chính Dương1, Hà Thanh Nguyễn1, Quốc Khánh Bạch1
1 Central Institute of Hematology - Blood Transfusion

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Abstract

The study was conducted on 60 patients who were first diagnosed and treated for Chronic Lymphocytic Leukemia – CLL at the National Institute of Hematology and Blood Transfusion, from September 2016 to December 2020. Study Methods: Cross-sectional descriptive. Use fluorescence in situ hybridization (FISH) assay with the MetaSystem XL ATM/TP53 and MetaSystem XL DLEU/LAMP/12cen probes. Laboratory test results show that 55.00% of CLL patients have genetic abnormalities. The rate of genetic abnormalities del(13q) is the highest, accounting for 38.33%. The rate of genetic abnormalities trisomy12 accounted for 15.00%, and the rate of genetic abnormalities del(11q) and del(17p) were lower, both accounting for 6.67%.

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References

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