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Date Published: 30/08/2023
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DOI: https://doi.org/10.51298/vmj.v529i1B.6386
Issue
Vol. 529 No. 1B (2023)
Section
Các bài báo
How to Cite
Vũ, Q. H., Dương, Q. C., Nguyễn, H. T., & Bạch, Q. K. (2023). GENETIC ABNORMALITIES OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED IN THE NATIONAL INSTITUE OF HEMATOLOGY AND BLOOD TRANSFUSION. Vietnam Medical Journal, 529(1B). https://doi.org/10.51298/vmj.v529i1B.6386

GENETIC ABNORMALITIES OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED IN THE NATIONAL INSTITUE OF HEMATOLOGY AND BLOOD TRANSFUSION

Quang Hưng Vũ1,, Quốc Chính Dương1, Hà Thanh Nguyễn1, Quốc Khánh Bạch1
1 Central Institute of Hematology - Blood Transfusion

Main Article Content

Abstract

The study was conducted on 60 patients who were first diagnosed and treated for Chronic Lymphocytic Leukemia – CLL at the National Institute of Hematology and Blood Transfusion, from September 2016 to December 2020. Study Methods: Cross-sectional descriptive. Use fluorescence in situ hybridization (FISH) assay with the MetaSystem XL ATM/TP53 and MetaSystem XL DLEU/LAMP/12cen probes. Laboratory test results show that 55.00% of CLL patients have genetic abnormalities. The rate of genetic abnormalities del(13q) is the highest, accounting for 38.33%. The rate of genetic abnormalities trisomy12 accounted for 15.00%, and the rate of genetic abnormalities del(11q) and del(17p) were lower, both accounting for 6.67%.

Article Details

Keywords

Chronic lymphocytic Leukemia (CLL), genetic abnormalities.

References

1. Molica S. et al (2006). Sex differences in incidence and outcome of chronic lymphocytic leukemia patients. Leuk lymphoma, vol. 47, pp. 1477-1480.
2. Watson L. et al (2008). Disease burden of chronic lymphocytic leukemia within the European Union, Eur J Haematol, vol.81, pp. 253-258.
3. Chadi N. et al (2015). Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era, JAMA Oncology, pp 1-10.
4. Anthony M. et al (2018). Pronosis testing pattern and outcome of Chronic Lymphocytic Leukemia Patients Stratified by fluorescence in situ hybridization/cytogenetics: A real- world Clinical Experience in the Connect CLL Registry, Clinical Lymphoma, Myeloma & Lekemia, vol. 18, no.2,pp. 114-124.
5. Amel S. et al. (2019). Cytogenetic landscape in 1021 newly diagnosed chronic lymphocytic leukemia, European Journal of Hematology, vol.01, pp. 01-07.
6. Daniel L. et al. (2016). The Dohner fluorescence of chronic lymphocytic leukemia (CLL): the CLL Research Consortium experience, Bristish Journal of Hematology, vol. 173, pp.105-113.
7. Phạm Quang Vinh (2013), Bất thường di truyền tế bào và bệnh máu ác tính, Nhà xuất bản Y học, Hà nội, Tr 184-206.
8. Hong X. Q. et al. (2008). Cytogenetic characterisation in Chinese patients with chronic lymphocytic leukemia: A prospective, multicenter study on 143 case analysed with interphase fluorescence in situ hybridsation, Leukemia & Lymphoma, vol. 49, no. 10, p 132, pp 705-722.
9. Rawas W. M. et al. (2018). B-cell chronic lymphocytic leukemia fluorescence in situ hybridisation panel findings at Tertiary Care Hospital in Saudi Arabia, Journal of Applied Hamatology, vol. 9, no. 3, pp.81-84.