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Date Published: 30/08/2023
Abstract Views: 110
Views pdf: 86
DOI: https://doi.org/10.51298/vmj.v529i1B.6407
Issue
Vol. 529 No. 1B (2023)
Section
Các bài báo
How to Cite
Trịnh, L. H., Trần, Đình A., & Đỗ, A. T. (2023). THE RESULT OF ADJUVANT VINORELBINE PLUS CISPLATIN IN COMPLETELY RESECTED STAGE IB-IIIA NON-SMALL CELL LUNG CANCER AT HANOI MEDICAL UNIVERSITY HOSPITAL. Vietnam Medical Journal, 529(1B). https://doi.org/10.51298/vmj.v529i1B.6407

THE RESULT OF ADJUVANT VINORELBINE PLUS CISPLATIN IN COMPLETELY RESECTED STAGE IB-IIIA NON-SMALL CELL LUNG CANCER AT HANOI MEDICAL UNIVERSITY HOSPITAL

Lê Huy Trịnh1,, Đình Anh Trần2, Anh Tú Đỗ3
1 HMU
2 Hanoi Medical University Hospital
3 K hospital

Main Article Content

Abstract

Objectives: Evaluating the result of adjuvant vinorelbine plus cisplatin in completely resected stage IB-IIIA NSCLC. Patients and methods: Descriptive study of 73 patients completely resected stage IB-IIIA non-small cell lung cancer were received adjuvant vinorelbine plus cisplatin chemotherapy at Hanoi Medical University Hospital from 01/2016 to 4/2022. Results: The mean age of 57,14 years old, male: female ratio was 2,85:1. 24 (32,9%) patients had postoperative stage IB disease, 25 (34.2%) had stage IIA disease, 14 (19,2%) had stage IIB disease and 10 (13,7%) had stage IIIA disease. The major histological type was adenocarcinoma (78.1%). Median disease free survival was 29,30 ± 1,63 months, and 3-year survival was 41,1%. Chemotherapy caused hematologic side effects in 66,67% of patients including neutropenia in 61,4% and grade 3/4 neutropenia in 27.4%. Non-hematologic toxic effects of chemotherapy were reported at low rates and almost mild (grade 1/2). Conclusions: The vinorelbine-cisplatin regimen is an effective regimen in the adjuvant treatment of non-small cell lung cancer, the study showed that the results in disease-free survival and overall survival were comparable to those of other studies in the world. The most common side effect was neutropenia, the other side effects were reported at low rate and usually mild.

Article Details

Keywords

Non-small cell lung cancer, vinorelbine, cisplatin, adjuvant chemotherapy

References

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