THAY ĐỔI NỒNG ĐỘ CYTOKINE HUYẾT THANH Ở BỆNH NHÂN VIÊM PHỔI CỘNG ĐỒNG DO VI KHUẨN

Abstract

Background: Community-acquired pneumonia (CAP) is one of the lower respiratory tract infections with high morbidity and mortality. Level of serum cytokine plays an important role in assessing the severity and prognosis of patients with pneumonia. Objectives: To evaluate changes in serum cytokine levels in patients with community-acquired bacterial pneumonia. Subjects and methods: Research were conducted among 78 CAP patients treated at Huu Nghị- Viet Tiep Hospital, Haiphong from January 2016 to December 2019. The patients’s sputum were cultured before they took antibiotics. Results and conclusions: Results of sputum culture: Gram-negative and Gram-positive bacteria were observerd among 62 patients (79.49%) and 16 patients (20.51%), respectively. Levels of cytokines at day 1 and day 7 of the CAP group were higher than the one of control group and the level at day 7 was lower than day 1. Level of TNF-α, IL-6 and IL-10 increased among patients with 5 most common bacteria. Compared with Gram-negative bacteria group, the level of IL-6 and IL-10 in Gram-positive bacteria group were higher, but TNF-α level was lower.