STUDY ON THE TREATMENT OF HYPERTENSION AND DIABETES OF THE PHYLLANTHUS ACIDUS
Main Article Content
Abstract
Objectives: The study below shows that the in Vitro inhibitory effect of these extracts of the Phyllanthus acidus on the actiVity of enzymes inVolVed in diabetes and hypertension such as α-glucosidase, α- amylase, dipeptidyl peptidase IV (DPP-IV) and angiotensin-conVerting enzyme (ACE). The total ethanol (TP) extract from the leaVes of Phyllanthus acidus and these fraction extracts such as ethyl ether (EE), ethyl acetate (EA), n-butanol (BU), and water (WA) haVe been tested with the aboVe enzymes. Result: The highest α-glucosidase inhibitory actiVity was in EE extract with IC50 of 26.57 μg/ml, and the highest ACE inhibitory actiVity was in EA with IC50 of
225.36 μg/ml. The highest α-amylase and DPP-IV inhibitory actiVity were in BU with IC50 of 41.81 μg/ml and 71.66 μg/ml, respectiVely. Conclusion: The leaVes of the Phyllanthus acidus are a Valuable and potential source of medicinal herbs in the treatment of diabetes and hypertension.
Article Details
Keywords
Phyllanthus acidus, α-glucosidase, α- amylase, angiotensin-conVerting enzyme (ACE),
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