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AN EVALUATION OF EFFICACY OF PATIENT-CONTROLLED THORACIC EPIDURAL ANALGESIA USING THE COMBINATION OF ROPIVACAINE AND FENTANYL FOR PATIENTS UNDERGOING OPEN ABDOMINAL SURGERY
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Abstract
Objectives: To evaluate the efficacy of postoperative patient-controlled epidural analgesia using the combination of ropivacain and fentanyl for open abdominal surgery. Methods: A randomized comparative clinical trial was performed on 3 groups of patients, each of which contained 35 cases with indication for open abdominal surgery. The medications applied for postoperative analgesia was made up of fentanyl 2mcg/ml combined with ropivacaine 0.1% in group I, ropivacaine 0.125% in group II and ropivacaine 0.2% in group III. The effectiveness of postoperative analgesia based on VAS score was documented at various investigated time points within 72 hours after surgery. Results: The VAS score at rest decreased to less than 3 after 15 minutes and at motion after 16 hours. The average of VAS score in the group II at rest and at motion was similar with the group III (p>0.05) and significantly lower than those in its two counterparts (p<0.05). The percentage of patients experiencing satisfaction and very satisfaction in the group II, I and III were 100%, 82.9% and 77.1%, respectively (p<0.001). Conclusion: Postoperative patient-controlled epidural analgesia using the combination of fentanyl and various concentrations of ropivacaine provided significantly analgesic efficacy to patients undergoing open abdominal surgery. Among the concentrations, ropivacaine 0,125% was the most efficient for postoperative analgesia when combined with fentanyl.
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Keywords
ropivacaine, fentanyl, oracic epidural anesthesia, open-abdominal surgery
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