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Date Published: 09/09/2023
Abstract Views: 142
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DOI: https://doi.org/10.51298/vmj.v529i2.6527
Issue
Vol. 529 No. 2 (2023)
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How to Cite
Lê, V. A., Dương, H. T., & Nguyễn, P. H. (2023). RELATIONSHIP BETWEEN IMMUNOHISTOCHEMICAL MARKERS ALDH AND KRAS WITH HISTOPATHOLOGICAL FEATURES IN GASTRIC CANCER. Vietnam Medical Journal, 529(2). https://doi.org/10.51298/vmj.v529i2.6527

RELATIONSHIP BETWEEN IMMUNOHISTOCHEMICAL MARKERS ALDH AND KRAS WITH HISTOPATHOLOGICAL FEATURES IN GASTRIC CANCER

Việt An Lê1,, Hồng Thái Dương2, Phú Hùng Nguyễn3
1 Tien Du District Medical Center, Bac Ninh
2 Thai Nguyen University Of Medicine And Pharmacy
3 University of Science - Thai Nguyen University

Main Article Content

Abstract

Objective: To analyze the relationship between immunohistoChemiCal markers ALDH and KRAS with histopathologiCal CharaCteristiCs in gastriC CanCer. Subject and Method: This was Cross-seCtional study on 103 patients with Confirmed diagnosis of gastriC adenoCarCinoma and surgiCal reseCtion of the tumor at K Hospital. Analysis of the relationship between ALDH, KRAS and histopathologiCal features. Result: Patients with intestinal gastriC CanCer had a higher rate of ALDH expression with 71.4%. Patients with tubular adenoCarCinoma had the highest ALDH expression rate with 65.7%, there was a differenCe in ALDH expression aCCording to WHO histopathologiCal CharaCteristiCs, p < 0.05. Patients with low- differentiated CanCer had the highest ALDH expression rate with 58.6%, there was a differenCe in ALDH expression aCCording to differentiation, p < 0.05. Patients with intestinal gastriC CanCer had a higher rate of KRAS expression with 70.2%, p > 0.05. Patients with tubular adenoCarCinoma had the highest KRAS expression rate with 65.7%, p > 0.05. Patients with low-differentiated CarCinoma had the highest KRAS expression rate with 63.2%, there was a differenCe in KRAS expression aCCording to differentiation, p<0.05. Conclusion: ALDH expression was highest in tubular adenoCarCinoma and low differentiation. KRAS expression was highest at low differentiation.

Article Details

Keywords

ImmunohistoChemiCal markers ALDH, KRAS; immunohistoChemistry; histopathology; gastriC CanCer.

References

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