EXPRESSION OF IMMUNE MARKERS ALDH AND KRAS IN GASTRIC CANCER

Việt An Lê1,, Hồng Thái Dương2, Phú Hùng Nguyễn3
1 Tien Du District Medical Center, Bac Ninh
2 Thai Nguyen University Of Medicine And Pharmacy
3 University of Science - Thai Nguyen University

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Abstract

Objectives: To desCribe the expression of immunohistoChemiCal markers ALDH and KRAS in gastriC CanCer. Methods: DesCriptiVe study, Cross- seCtional study design on 103 patients with a definitiVe diagnosis of gastriC CanCer and surgiCal remoVal of the tumor at K Hospital. EValuation of expression leVels of markers ALDH, KRAS in CanCer and Control samples. Results: The proportion of patients expressing ALDH at leVel 1+ aCCounted for 17.5%, leVel 2+ was 35.0% and 3+ aCCounted for 15.5%. The perCentage of patients with positiVe ALDH was 68.0%. The proportion of patients expressing KRAS at leVel 1+ aCCounts for 10.7%, leVel 2+ is 38.8% and 3+ aCCounts for 16.5%. The perCentage of patients with positiVe KRAS was 55.3%. There were 71.4% Cases of Co-expression of ALDH and KRAS. The rate of expression of a single marker was 27.2%. Two markers expressed simultaneously aCCounted for the highest rate with 48.5%. Conclusion: ImmunohistoChemiCal markers ALDH and KRAS Can be expressed alone or Co-expressed at a relatiVely high rate in gastriC CanCer patients.

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References

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