TREATMENT RESULTS OF CHILDREN'S TUBERCULOSIS FOLLOWING THE GUIDELINES FROM THE NATIONAL TUBERCULOSIS PROGRAM AT PEDIATRICS DEPRTMENT OF NATIONAL LUNG HOSPITAL

Thị Hằng Nguyễn1,, Ngọc Sỹ Đinh2, Thanh Vân Hoàng3
1 HMU
2 Vietnam General Medical Association
3 Lung central hospital

Main Article Content

Abstract

Objectives: to describe the results of Tuberculosis (TB) treatment in children according to the Guidelines of the National Tuberculosis Program at the Department of Pediatrics - National Lung Hospital. Methods: A cross-sectional descriptive study was carried out among 333 pediatric patients diagnosed and treated for TB according to the guidelines of National Tuberculosis Program at the Department of Pediatrics -National Lung Hospital from January 1st, 2017 to January 1st, 2018. Results: Nearly half of the pediatric patients were under the age of 5 (48.8%) with the majority was pulmonary TB (66.4%). TB located in 1 organ accounted for 70.3%; TB in 2 organs was 25.5%. According to the results of antibiogram, the majority was sensitive TB (91.3%), the rate of multi drug resistant and super-resistant tuberculosis were low (<3%). The adverse effects of the drug were rashes and itching on the skin (56.0%) and increased liver enzymes (48.0%). Most of the pediatric patients got successful treatment results (95.8%). The overall dropout rate was 1.8%, of which the dropout rate of pulmonary TB was 2.0%, extrapulmonary TB was 0.9%. The dropout rate in the age group of less than 5 was 2.4%, higher than that of other age groups. The overall mortality rate was 2.4%, of which the mortality rate in the pulmonary tuberculosis group was 3%, and in the extrapulmonary tuberculosis group was 1.8%. Mortality in the under 5 age group accounted for 3.1% and the 10-15 year old group accounted for 3.0%.

Article Details

References

WHO. Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2014.
2. Tilahun G, Gebre-Selassie S. Treatment outcomes of childhood tuberculosis in Addis Ababa: a five-year retrospective analysis. BMC Public Health. 2016;16(1):612.
3. Chương trình Chống lao Quốc gia. Hướng dẫn chẩn đoán, điều trị và dự phòng bệnh lao. . 2015.
4. Vukugah TA, Akoku DA, Tchoupa MM.. Epidemiology of Pediatric Tuberculosis and Factors Associated with Unsuccessful Treatment Outcomes in the Centre Region of Cameroon: A Three-Year Retrospective Cohort Study. Interdiscip Perspect Infect Dis. 2022;2022:2236110. doi:10.1155/2022/22361107.
5. Hamid M, Brooks MB, Madhani F, et al.. Risk factors for unsuccessful tuberculosis treatment outcomes in children. PLoS One. 2019;14(9): e0222776. doi:10.1371/journal.pone.0222776.
6. Abdusalomova M, Denisiuk O, Davtyan H, at al.. Adverse Drug Reactions among Children with Tuberculosis in Tashkent, Uzbekistan, 2019. Int J Environn Res Public Health. 2021;18(14):7574. doi:10.3390/ijerph18147574.
7. Blount RJ, Bao Tran, Jarlsberg LG, at al. Childhood tuberculosis in northern Viet Nam: a review of 103 cases. PLoS One. 2014; 9(5)doi:10.1371/journal.pone.0097267. eCollection 2014.
8. Nhung NV, Hòa NB, Huyền PK, Hennig C, at al. Tuberculosis case notification data in Viet Nam, 2007 to 2012. Western Pac Surveill Response J. 2015;6(6):7 - 14. doi:10.2471/WPSAR.2014.5.2.005.